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Infra-red absorption spectra of pyrimidine nucleotides in H_2O and D_2O solution

Sinsheimer, Robert L. and Nutter, Robert L. and Hopkins, George R. (1955) Infra-red absorption spectra of pyrimidine nucleotides in H_2O and D_2O solution. Biochimica et Biophysica Acta, 18 . pp. 13-27. ISSN 0006-3002. https://resolver.caltech.edu/CaltechAUTHORS:20160527-120928635

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Abstract

Infra-red absorption spectra of several pyrimidine nucleosides and nucleotides have been obtained in H_2O and in D_2O solution. By correlation of the appearance and disappearance of absorption bands upon variation of the pH of these solutions with the known dissociation constants of amine, enolic, and phosphate groups, the assignment of bands to specific atomic groups has been greatly facilitated. Assignments are presented for various ionic phosphate frequencies, bond stretching and deformation frequencies, frequencies associated with amine-ammonium and keto-enol transitions, and frequencies associated with certain conjugated ring structures. Evidence is presented indicating the existence of strong intra-molecular hydrogen bonds. These data are correlated with previous infra-red and ultra-violet absorption and X-ray diffraction data pertaining to these compounds.


Item Type:Article
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http://dx.doi.org/10.1016/0006-3002(55)90003-2DOIArticle
http://www.sciencedirect.com/science/article/pii/0006300255900032PublisherArticle
Additional Information:© 1955 Elsevier B.V. Received 10 March 1955. This Research was supported in major part by a grant from the American Cancer Society acting through the Committee on Growth of the National Research Council. A preliminary report of portions of this work was presented before the physics section of the Iowa Academy of Science meeting, March, 1952. The cooperation of the Iowa State College Institute for Atomic Research, which made available to us the recording infra-red spectrophotometers, is gratefully acknowledged. We are indebted to Mr. Richard Hedges for assistance in the operation of the spectrophotometers. It is a pleasure to note the valuable discussions concerning the interpretations of these infra-red spectra which were held with Dr. Jesse F. Scott and Dr. Robert Rundle.
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American Cancer SocietyUNSPECIFIED
National Research CouncilUNSPECIFIED
Record Number:CaltechAUTHORS:20160527-120928635
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160527-120928635
Official Citation:Robert L. Sinsheimer, Robert L. Nutter, George R. Hopkins, Infra-red absorption spectra of pyrimidine nucleotides in H2O and D2O solution, Biochimica et Biophysica Acta, Volume 18, 1955, Pages 13-27, ISSN 0006-3002, http://dx.doi.org/10.1016/0006-3002(55)90003-2. (http://www.sciencedirect.com/science/article/pii/0006300255900032)
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ID Code:67454
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:27 May 2016 21:17
Last Modified:03 Oct 2019 10:06

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