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A Reversible Photochemical Alteration of Uracil and Uridine

Sinsheimer, Robert L. and Hastings, Ruth (1949) A Reversible Photochemical Alteration of Uracil and Uridine. Science, 110 (2864). pp. 525-526. ISSN 0036-8075. doi:10.1126/science.110.2864.525.

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Various lines of evidence (1, 3, 4) have suggested that the primary effect of lethal and mutagenic doses of ultraviolet radiations upon living cells may be partially reversible, or at least compensated within the cell. In connection with a general study of the photochemistry of nucleic acid derivatives, we have discovered that, under certain conditions, the initial photodecomposition product of the pyrimidine, uracil, and the corresponding product of the ribose nucleotide, uridine, may spontaneously revert to the initial substances, uracil and uridine, respectively.

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Additional Information:© 1949 American Association for the Advancement of Science. This study was supported by the American Cancer Society, acting through the Committee on Growth of the National Research Council.
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American Cancer SocietyUNSPECIFIED
National Research CouncilUNSPECIFIED
Issue or Number:2864
Record Number:CaltechAUTHORS:20160531-081226310
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Official Citation:A Reversible Photochemical Alteration of Uracil and Uridine Robert L. Sinsheimer and Ruth Hastings Science 18 Nov 1949: Vol. 110, Issue 2864, pp. 525-526 DOI: 10.1126/science.110.2864.525
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67472
Deposited By: Ruth Sustaita
Deposited On:31 May 2016 23:38
Last Modified:11 Nov 2021 00:33

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