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A Reversible Photochemical Alteration of Uracil and Uridine

Sinsheimer, Robert L. and Hastings, Ruth (1949) A Reversible Photochemical Alteration of Uracil and Uridine. Science, 110 (2864). pp. 525-526. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20160531-081226310

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Abstract

Various lines of evidence (1, 3, 4) have suggested that the primary effect of lethal and mutagenic doses of ultraviolet radiations upon living cells may be partially reversible, or at least compensated within the cell. In connection with a general study of the photochemistry of nucleic acid derivatives, we have discovered that, under certain conditions, the initial photodecomposition product of the pyrimidine, uracil, and the corresponding product of the ribose nucleotide, uridine, may spontaneously revert to the initial substances, uracil and uridine, respectively.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.110.2864.525DOIArticle
http://science.sciencemag.org/content/110/2864/525PublisherArticle
Additional Information:© 1949 American Association for the Advancement of Science. This study was supported by the American Cancer Society, acting through the Committee on Growth of the National Research Council.
Funders:
Funding AgencyGrant Number
American Cancer SocietyUNSPECIFIED
National Research CouncilUNSPECIFIED
Issue or Number:2864
Record Number:CaltechAUTHORS:20160531-081226310
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160531-081226310
Official Citation:A Reversible Photochemical Alteration of Uracil and Uridine Robert L. Sinsheimer and Ruth Hastings Science 18 Nov 1949: Vol. 110, Issue 2864, pp. 525-526 DOI: 10.1126/science.110.2864.525
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67472
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:31 May 2016 23:38
Last Modified:03 Oct 2019 10:06

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