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Is The Nucleic Acid Message in a Two-Symbol Code?

Sinsheimer, Robert L. (1959) Is The Nucleic Acid Message in a Two-Symbol Code? Journal of Molecular Biology, 1 (3). pp. 218-220. ISSN 0022-2836. doi:10.1016/S0022-2836(59)80028-0.

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In order to account for the diversity of adenine : guanine ratios in the deoxyribonucleic acids (DNA) of various microorganisms, it is proposed that the code in DNA is a two-symbol code. Specifically, it is proposed that the code is a sequence of 6-amino or 6-keto groups and thus adenine is equivalent to cytosine and guanine to thymine (or, in RNA, to uracil). This hypothesis also provides a convenient explanation of the near-equivalence of 6-amino and 6-keto nucleotides in the total RNA of various organisms.

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Additional Information:© 1959 Elsevier Ltd. Received 27 April 1959.
Issue or Number:3
Record Number:CaltechAUTHORS:20160531-082128951
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Official Citation:Robert L. Sinsheimer, Is the nucleic acid message in a two-symbol code?, Journal of Molecular Biology, Volume 1, Issue 3, 1959, Pages 218-220, ISSN 0022-2836, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67475
Deposited By: Ruth Sustaita
Deposited On:31 May 2016 23:36
Last Modified:11 Nov 2021 00:33

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