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The action of pancreatic desoxyribonuclease. I. Isolation of mono- and dinucleotides

Sinsheimer, Robert L. and Koerner, James F. and Vadla, Jostein and Lunan, K. (1954) The action of pancreatic desoxyribonuclease. I. Isolation of mono- and dinucleotides. Journal of Biological Chemistry, 208 (1). pp. 445-459. ISSN 0021-9258.

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The nature of the products of the action of pancreatic desoxyribonuclease (DNase) upon highly polymerized desoxyribonucleic acid (DNA) has been the subject of numerous investigations. Titrimetric studies (1-5) have revealed that, during the digestion, approximately one secondary phosphate group becomes titratable per 4 phosphorus atoms, which may be interpreted to mean that the products are, on the average, of the magnitude of tetranucleotides. More recently, ionophoretic (9), diffusion (5), and dialysis (10, 11) studies of the digest have suggested that it contains a complex mixture of polynucleotides of a range of magnitudes.

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Additional Information:© 1954 American Society for Biochemistry and Molecular Biology. Received for publication, November 30, 1953. The work described in this paper was accomplished with the aid of grants from the Rockefeller Foundation and the United States Public Health Service.
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Rockefeller FoundationUNSPECIFIED
U.S. Public Health Service (USPHS)UNSPECIFIED
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Official Citation:THE ACTION OF PANCREATIC DESOXYRIBONUCLEASE: I. ISOLATION OF MONO- AND DINUCLEOTIDES Robert L. Sinsheimer and With the technical assistance of James F. Koerner, Jostein Vadla, and K. Lunan J. Biol. Chem. 1954 208: 445-459.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67482
Deposited By: Ruth Sustaita
Deposited On:31 May 2016 23:32
Last Modified:03 Oct 2019 10:06

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