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Vegetative λ DNA: III. Pulse-labeled Components

Young, Elton T. and Sinsheimer, Robert L. (1968) Vegetative λ DNA: III. Pulse-labeled Components. Journal of Molecular Biology, 33 (1). pp. 49-59. ISSN 0022-2836. doi:10.1016/0022-2836(68)90280-5.

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The structures of λ DNA labeled during short pulses of [^3H]thymine at various times after infection have been studied by ultracentrifugal analysis. Circular DNA's, both the supercoiled form and an open form, are the main DNA components synthesized in the first half of the latent period. The open circular form is the most rapidly synthesized and may be a precursor to the supercoiled DNA. During the later period of progeny DNA accumulation the open circular form and a heterogeneous, more rapidly sedimenting component(s) are synthesized during such pulses. These are apparently involved in the generation of the linear, viral DNA.

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Additional Information:© 1968 Elsevier Ltd. Received 12 September 1967. This research was supported in part by research grants RG6965 and GM13554 from the U.S. Public Health Service.
Funding AgencyGrant Number
U.S. Public Health Service (USPHS)RG6965
U.S. Public Health Service (USPHS)GM13554
Issue or Number:1
Record Number:CaltechAUTHORS:20160601-093438720
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Official Citation:Elton T. Young, Robert L. Sinsheimer, Vegetative λ DNA, Journal of Molecular Biology, Volume 33, Issue 1, 1968, Pages 49-59, ISSN 0022-2836, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67528
Deposited By: Ruth Sustaita
Deposited On:01 Jun 2016 20:40
Last Modified:11 Nov 2021 03:50

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