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Therapeutic efficacy of HER3-targeted nanobiologics on resistant tumors

Medina-Kauwe, L. and Sims, J. and Taguiam, M. and Hanson, C. and Alonso-Valenteen, F. and Cui, X. and Chung, A. and Gray, H. and Gross, Z. and Giuliano, A. (2016) Therapeutic efficacy of HER3-targeted nanobiologics on resistant tumors. Cancer Research, 76 (S4). Art. No. P6-13. ISSN 0008-5472. https://resolver.caltech.edu/CaltechAUTHORS:20160610-081611441

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Abstract

Elevated cell surface levels of the human epidermal growth factor receptor subunit 3 (HER3) are associated with resistance to a number of signal-blocking breast cancer treatments, including inhibitors of EGF-R (lapatinib), HER2 (lapatinib, trastuzumab, T-DM1), HER2-3 (pertuzumab), and combination therapy. Additionally, HER3 elevation has been identified on "untarget-able" tumors such as triple-negative breast cancer (TNBC), including TNBC with acquired resistance to EGF-R inhibition. Patients with such refractory tumors currently have limited treatment options and a poor prognosis. Moreover, as up to 70% of cases resist or acquire resistance to signal-blocking therapies, an alternative approach addressing this important clinical problem has the potential for significant clinical impact.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1158/1538-7445.SABCS15-P6-13-10DOIArticle
http://cancerres.aacrjournals.org/content/76/4_Supplement/P6-13-10PublisherArticle
ORCID:
AuthorORCID
Gray, H.0000-0002-7937-7876
Additional Information:© 2016 American Association for Cancer Research.
Issue or Number:S4
Record Number:CaltechAUTHORS:20160610-081611441
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160610-081611441
Official Citation:Therapeutic efficacy of HER3-targeted nanobiologics on resistant tumors L Medina-Kauwe, J Sims, M Taguiam, C Hanson, F Alonso-Valenteen, X Cui, A Chung, H Gray, Z Gross, and A Giuliano Cancer Res February 15, 2016 76:P6-13-10; doi:10.1158/1538-7445.SABCS15-P6-13-10
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67810
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:10 Jun 2016 16:02
Last Modified:22 Nov 2019 09:58

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