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The Replication of Bacteriophage MS2 II. An in vivo Specificity for the Synthesis of Infective RNA

Davis, James E. and Pfeifer, Dietrich and Sinsheimer, Robert L. (1964) The Replication of Bacteriophage MS2 II. An in vivo Specificity for the Synthesis of Infective RNA. Journal of Molecular Biology, 10 (1). pp. 1-9. ISSN 0022-2836. doi:10.1016/S0022-2836(64)80022-X.

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Multiple infection with wild-type MS2 and a plaque-morphology mutant of MS2 is demonstrated. An infectivity assay for phage RNA is described and growth curves for intracellular infective RNA in MS2-infected cells are presented which demonstrate the presence of a pool of infective RNA prior to the appearance of progeny virus particles. Experiments are described which indicate that the synthetic system established in an MS2-infected cell will not be used to produce infective RNA of a genetically distinguishable superinfecting phage.

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Additional Information:© 1964 Elsevier Ltd. Received 19 March 1964. This research was supported, in part, by a grant (RG-6965) from the U.S. Public Health Service. One of us (J. E. D.) was a postdoctoral fellow of the U.S. Public Health Service during part of this research period.
Funding AgencyGrant Number
U.S. Public Health Service (USPHS)RG-6965
U.S. Public Health Service (USPHS) Postdoctoral FellowUNSPECIFIED
Issue or Number:1
Record Number:CaltechAUTHORS:20160610-103646469
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Official Citation:James E. Davis, Dietrich Pfeifer, Robert L. Sinsheimer, The replication of bacteriophage MS2, Journal of Molecular Biology, Volume 10, Issue 1, 1964, Pages 1-9, ISSN 0022-2836, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67827
Deposited By: Ruth Sustaita
Deposited On:10 Jun 2016 18:18
Last Modified:11 Nov 2021 03:55

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