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Gene-Sized DNA Molecules of the Oxytricha Macronucleus have the Same Terminal Sequence

Lawn, Richard M. (1977) Gene-Sized DNA Molecules of the Oxytricha Macronucleus have the Same Terminal Sequence. Proceedings of the National Academy of Sciences of the United States of America, 74 (10). pp. 4325-4328. ISSN 0027-8424.

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The DNA in the macronucleus of the ciliated protozoan Oxytricha exists as small linear molecules with a number average size of about 3000 base pairs. Most, and possibly all, of these DNA molecules contain the same inverted terminal repeat sequence of approximately 26 base pairs. In addition to its terminal location, two inverted copies of this same sequence surround single-strand interruptions within these DNA molecules. This sequence arrangement may function in the processing of these molecules from large chromosomal precursors or in the subsequent replication of these small linear DNAs during cell reproduction.

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Additional Information:Copyright © 1977 by the National Academy of Sciences Communicated by David M. Prescott, August 2, 1977 I thank David Prescott for his support of this research and assistance in preparing this manuscript, and Glenn Herrick and Ronald Wesley for communication of unpublished results. I also thank Tom Maniatis for assistance in learning the DNA sequencing techniques. This work was supported by National Institutes of Health Grant GM19199 to D. Prescott. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U. S. C. §1734 solely to indicate this fact.
Subject Keywords:palindromes; inverted terminal repeats; DNA sequence; ciliated protozoan
Issue or Number:10
Record Number:CaltechAUTHORS:LAWpnas77
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:6827
Deposited By: Archive Administrator
Deposited On:23 Dec 2006
Last Modified:02 Oct 2019 23:36

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