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Effect of phleomycin upon replication of bacteriophage ΦX174

Pitts, John D. and Sinsheimer, Robert L. (1966) Effect of phleomycin upon replication of bacteriophage ΦX174. Journal of Molecular Biology, 15 (2). pp. 676-680. ISSN 0022-2836. doi:10.1016/S0022-2836(66)80136-5.

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Earlier work has shown that the replication of bacteriophage ΦX174 involves three stages of DNA synthesis: (i) the addition of a complementary strand to the single stranded parental DNA (Sinsheimer, Starman, Nagler & Guthrie, 1962) to produce a "replicative form"; (ii) the semi-conservative replication of this replicative form; and (iii) the synthesis of single-stranded DNA for progeny phage by a conservative process (Denhardt & Sinsheimer, 1965b). The addition of chloramphenicol, which inhibits protein synthesis, does not affect stages (i) and (ii) but does prevent stage (iii).

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Additional Information:© 1966 Elsevier Ltd. Received 29 November 1965. The gift of phleomycin by Dr Lein, Bristol Laboratories, is gratefully acknowledged. This research was supported, in part, by grant RG6965 from the U.S. Public Health Service.
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U.S. Public Health Service (USPHS)RG6965
Issue or Number:2
Record Number:CaltechAUTHORS:20160617-092651406
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Official Citation:John D. Pitts, Robert L. Sinsheimer, Effect of phleomycin upon replication of bacteriophage ΦX174, Journal of Molecular Biology, Volume 15, Issue 2, 1966, Pages 676-680, ISSN 0022-2836, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:68471
Deposited By: Ruth Sustaita
Deposited On:17 Jun 2016 17:25
Last Modified:11 Nov 2021 04:00

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