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In vivo dark-field reflection-mode photoacoustic microscopy

Maslov, Konstantin and Stoica, Gheorghe and Wang, Lihong V. (2005) In vivo dark-field reflection-mode photoacoustic microscopy. Optics Letters, 30 (6). pp. 625-627. ISSN 0146-9592. doi:10.1364/OL.30.000625.

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Reflection-mode photoacoustic microscopy with dark-field laser pulse illumination and high-numerical-aperture ultrasonic detection is designed and implemented in noninvasively imaged blood vessels in the skin in vivo. Dark-field optical illumination minimizes the interference caused by strong photoacoustic signals from superficial structures. A high-numerical-aperture acoustic lens provides high lateral resolution, 45–120μm in this system. A broadband ultrasonic detection system provides high axial resolution, estimated to be ∼15μm. The optical illumination and ultrasonic detection are in a coaxial confocal configuration for optimal image quality. The system is capable of imaging optical-absorption contrast as deep as 3mm in biological tissue.

Item Type:Article
Related URLs:
URLURL TypeDescription
Maslov, Konstantin0000-0003-3408-8840
Stoica, Gheorghe0000-0001-8071-4828
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2005 Optical Society of America. Received October 4, 2004. This project was sponsored by National Institutes of Health grants R01 EB000712 and R01 NS46214.
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 NS46214
Issue or Number:6
Classification Code:OCIS codes: 170.3880, 170.5120, 180.5810
Record Number:CaltechAUTHORS:20160617-095623519
Persistent URL:
Official Citation:K. Maslov, G. Stoica, and L. Wang, "In vivo dark-field reflection-mode photoacoustic microscopy," Opt. Lett. 30, 625-627 (2005)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:68474
Deposited By: Tony Diaz
Deposited On:17 Jun 2016 17:26
Last Modified:11 Nov 2021 04:00

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