Maslov, Konstantin and Stoica, Gheorghe and Wang, Lihong V. (2005) In vivo dark-field reflection-mode photoacoustic microscopy. Optics Letters, 30 (6). pp. 625-627. ISSN 0146-9592. doi:10.1364/OL.30.000625. https://resolver.caltech.edu/CaltechAUTHORS:20160617-095623519
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Abstract
Reflection-mode photoacoustic microscopy with dark-field laser pulse illumination and high-numerical-aperture ultrasonic detection is designed and implemented in noninvasively imaged blood vessels in the skin in vivo. Dark-field optical illumination minimizes the interference caused by strong photoacoustic signals from superficial structures. A high-numerical-aperture acoustic lens provides high lateral resolution, 45–120μm in this system. A broadband ultrasonic detection system provides high axial resolution, estimated to be ∼15μm. The optical illumination and ultrasonic detection are in a coaxial confocal configuration for optimal image quality. The system is capable of imaging optical-absorption contrast as deep as 3mm in biological tissue.
Item Type: | Article | ||||||||
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Additional Information: | © 2005 Optical Society of America. Received October 4, 2004. This project was sponsored by National Institutes of Health grants R01 EB000712 and R01 NS46214. | ||||||||
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Issue or Number: | 6 | ||||||||
Classification Code: | OCIS codes: 170.3880, 170.5120, 180.5810 | ||||||||
DOI: | 10.1364/OL.30.000625 | ||||||||
Record Number: | CaltechAUTHORS:20160617-095623519 | ||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20160617-095623519 | ||||||||
Official Citation: | K. Maslov, G. Stoica, and L. Wang, "In vivo dark-field reflection-mode photoacoustic microscopy," Opt. Lett. 30, 625-627 (2005) | ||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||
ID Code: | 68474 | ||||||||
Collection: | CaltechAUTHORS | ||||||||
Deposited By: | Tony Diaz | ||||||||
Deposited On: | 17 Jun 2016 17:26 | ||||||||
Last Modified: | 11 Nov 2021 04:00 |
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