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In vivo dark-field reflection-mode photoacoustic microscopy

Maslov, Konstantin and Stoica, Gheorghe and Wang, Lihong V. (2005) In vivo dark-field reflection-mode photoacoustic microscopy. Optics Letters, 30 (6). pp. 625-627. ISSN 0146-9592. doi:10.1364/OL.30.000625. https://resolver.caltech.edu/CaltechAUTHORS:20160617-095623519

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Abstract

Reflection-mode photoacoustic microscopy with dark-field laser pulse illumination and high-numerical-aperture ultrasonic detection is designed and implemented in noninvasively imaged blood vessels in the skin in vivo. Dark-field optical illumination minimizes the interference caused by strong photoacoustic signals from superficial structures. A high-numerical-aperture acoustic lens provides high lateral resolution, 45–120μm in this system. A broadband ultrasonic detection system provides high axial resolution, estimated to be ∼15μm. The optical illumination and ultrasonic detection are in a coaxial confocal configuration for optimal image quality. The system is capable of imaging optical-absorption contrast as deep as 3mm in biological tissue.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1364/OL.30.000625DOIArticle
ORCID:
AuthorORCID
Maslov, Konstantin0000-0003-3408-8840
Stoica, Gheorghe0000-0001-8071-4828
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2005 Optical Society of America. Received October 4, 2004. This project was sponsored by National Institutes of Health grants R01 EB000712 and R01 NS46214.
Funders:
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 NS46214
Issue or Number:6
Classification Code:OCIS codes: 170.3880, 170.5120, 180.5810
DOI:10.1364/OL.30.000625
Record Number:CaltechAUTHORS:20160617-095623519
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160617-095623519
Official Citation:K. Maslov, G. Stoica, and L. Wang, "In vivo dark-field reflection-mode photoacoustic microscopy," Opt. Lett. 30, 625-627 (2005)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:68474
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:17 Jun 2016 17:26
Last Modified:11 Nov 2021 04:00

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