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Inhibition of Ribonucleic Acid Bacteriophage Growth by Actinomycin D

Lunt, Mary R. and Sinsheimer, Robert L. (1966) Inhibition of Ribonucleic Acid Bacteriophage Growth by Actinomycin D. Journal of Molecular Biology, 18 (3). pp. 541-546. ISSN 0022-2836. doi:10.1016/S0022-2836(66)80042-6.

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In the study of RNA bacteriophage (MS2) replication, the analysis of virus-specific RNA or protein synthesis is facilitated by inhibition of host RNA synthesis. Such inhibition can be produced with actinomycin D, which will penetrate spheroplasts of Escherichia coli (Haywood & Sinsheimer, 1963; Mach & Tatum, 1963) or EDTA treated E. coli cells (Lieve, 1965a,b). Under these conditions, some viral replication occurs. However, it is important to note that this replication is greatly reduced from normal (see also Haywood & Sinsheimer, 1965) and there appears to be, particularly at later stages of infection, a significant distortion of the pattern of RNA synthesis.

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Additional Information:© 1966 Elsevier Ltd. Received 21 February 1966. This research was supported in part by grant RG6965 of the U.S. Public Health Service.
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U.S. Public Health Service (USPHS)RG6965
Issue or Number:3
Record Number:CaltechAUTHORS:20160617-102802686
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Official Citation:Mary R. Lunt, Robert L. Sinsheimer, Inhibition of ribonucleic acid bacteriophage growth by actinomycin D, Journal of Molecular Biology, Volume 18, Issue 3, 1966, Pages 541-546, ISSN 0022-2836, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:68478
Deposited By: Ruth Sustaita
Deposited On:17 Jun 2016 17:39
Last Modified:11 Nov 2021 04:00

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