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Process of Infection with Bacteriophage øX174: XIV. Studies on Macromolecular Synthesis during Infection with a Lysis-defective Mutant

Lindqvist, Björn H. and Sinsheimer, Robert L. (1967) Process of Infection with Bacteriophage øX174: XIV. Studies on Macromolecular Synthesis during Infection with a Lysis-defective Mutant. Journal of Molecular Biology, 28 (1). pp. 87-94. ISSN 0022-2836. http://resolver.caltech.edu/CaltechAUTHORS:20160617-103601226

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Abstract

Bacterial DNA, total RNA and protein synthesis have been studied in Escherichia coli C infected with a lysis-defective mutant of bacteriophage øX174. It has been found that host DNA synthesis ceases about 12 to 14 minutes after infection at 40°C, whereas RNA and protein synthesis continue throughout the infection. Host DNA synthesis does not stop when chloramphenicol (30 or 100 μg/ml.) is present before and during the infection. This result indicates that a phage-specific protein is responsible for the cessation of host DNA synthesis.


Item Type:Article
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http://dx.doi.org/10.1016/S0022-2836(67)80079-2DOIArticle
http://www.sciencedirect.com/science/article/pii/S0022283667800792PublisherArticle
Additional Information:© 1967 Elsevier Ltd. Received 14 February 1967, and in revised form 19 May 1967. We acknowledge the excellent technical assistance of Miss Joan Dembrowski. The research was supported in part by U.S. Public Health Service research grant GM 13554.
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U.S. Public Health Service (USPHS)GM 13554
Record Number:CaltechAUTHORS:20160617-103601226
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160617-103601226
Official Citation:Björn H. Lindqvist, Robert L. Sinsheimer, Process of infection with bacteriophage øX174, Journal of Molecular Biology, Volume 28, Issue 1, 1967, Pages 87-94, ISSN 0022-2836, http://dx.doi.org/10.1016/S0022-2836(67)80079-2. (http://www.sciencedirect.com/science/article/pii/S0022283667800792)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:68479
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:17 Jun 2016 18:14
Last Modified:17 Jun 2016 18:14

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