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Cuffing-based photoacoustic flowmetry in humans in the optical diffusive regime

Zhou, Yong and Liang, Jinyang and Wang, Lihong V. (2016) Cuffing-based photoacoustic flowmetry in humans in the optical diffusive regime. Journal of Biophotonics, 9 (3). pp. 208-212. ISSN 1864-063X. PMCID PMC4775313. doi:10.1002/jbio.201500181. https://resolver.caltech.edu/CaltechAUTHORS:20160617-110123080

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Abstract

Measuring blood flow speed in the optical diffusive regime in humans has been a long standing challenge for photoacoustic tomography. In this work, we proposed a cuffing-based method to quantify blood flow speed in humans with a handheld photoacoustic probe. By cuffing and releasing the blood vessel, we can measure the blood flow speed downstream. In phantom experiments, we demonstrated that the minimum and maximum measurable flow speeds were 0.035 mm/s and 42 mm/s, respectively. In human experiments, flow speeds were measured in three different blood vessels: a radial artery in the right forearm, a radial artery in the index finger of the right hand, and a radial vein in the right forearm. Taking advantage of the handheld probe, our method can potentially be used to monitor blood flow speed in the clinic and at the bedside.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/jbio.201500181DOIArticle
http://onlinelibrary.wiley.com/doi/10.1002/jbio.201500181/abstractPublisherArticle
http://onlinelibrary.wiley.com/doi/10.1002/jbio.201500181/suppinfoPublisherSupporting Information
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Manuscript Received: 19 JUN 2015. Manuscript Revised: 15 SEP 2015. Manuscript Accepted: 26 SEP 2015. Version of Record online: 30 OCT 2015.
Subject Keywords:blood flow; optical diffusive regime; photoacoustic tomography; cuffing; in human
Issue or Number:3
PubMed Central ID:PMC4775313
DOI:10.1002/jbio.201500181
Record Number:CaltechAUTHORS:20160617-110123080
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160617-110123080
Official Citation:Zhou, Y., Liang, J. and Wang, L. V. (2016), Cuffing-based photoacoustic flowmetry in humans in the optical diffusive regime. J. Biophoton., 9: 208–212. doi: 10.1002/jbio.201500181
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:68482
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:17 Jun 2016 18:20
Last Modified:11 Nov 2021 04:00

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