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In vivo photoacoustic tomography of myoglobin oxygen saturation

Lin, Li and Yao, Junjie and Li, Lei and Wang, Lihong V. (2016) In vivo photoacoustic tomography of myoglobin oxygen saturation. Journal of Biomedical Optics, 21 (6). Art. No. 061002. ISSN 1083-3668. PMCID PMC5397140.

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Myoglobin is an essential oxygen-binding hemoprotein in skeletal and cardiac muscles that buffers intracellular oxygen (O_2) concentration in response to hypoxia or elevated muscle activities. We present a method that uses photoacoustic computed tomography to measure the distribution of myoglobin in tissue and the oxygen saturation of myoglobin (sO_2-Mb). From photoacoustic measurements of mice in different oxygenation states, we performed calibration-free quantification of the sO_2 –Mb change in the backbone muscle in vivo.

Item Type:Article
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URLURL TypeDescription CentralArticle
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2015 SPIE. Paper 150407SSR received Jun. 16, 2015; accepted for publication Sep. 11, 2015; published online Dec. 17, 2015. The authors would like to thank Professor James Ballard for close reading of this paper. We also thank Guo Li, Dr. Junhui Shi, and Dr. Lidai Wang for useful discussions. This work was supported in part by the National Institutes of Health Grants Nos. DP1 EB016986 (NIH Director’s Pioneer Award), R01 CA186567 (NIH Director’s Transformative Research Award), and R01 EB016963. L.V.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.
Funding AgencyGrant Number
NIHDP1 EB016986
NIHR01 CA186567
NIHR01 EB016963
Subject Keywords:myoglobin; oxygen saturation; calibration-free photoacoustic tomography; backbone muscle
PubMed Central ID:PMC5397140
Record Number:CaltechAUTHORS:20160617-141105522
Persistent URL:
Official Citation:Lin L, Yao J, Li L, Wang LV; In vivo photoacoustic tomography of myoglobin oxygen saturation. J. Biomed. Opt. 0001;21(6):061002. doi:10.1117/1.JBO.21.6.061002
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:68489
Deposited By: Tony Diaz
Deposited On:18 Jun 2016 18:27
Last Modified:27 Feb 2019 17:43

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