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A Constrained Variable Projection Reconstruction Method for Photoacoustic Computed Tomography Without Accurate Knowledge of Transducer Responses

Sheng, Qiwei and Wang, Kun and Matthews, Thomas P. and Xia, Jun and Zhu, Liren and Wang, Lihong V. and Anastasio, Mark A. (2015) A Constrained Variable Projection Reconstruction Method for Photoacoustic Computed Tomography Without Accurate Knowledge of Transducer Responses. IEEE Transactions on Medical Imaging, 34 (12). pp. 2443-2458. ISSN 0278-0062. PMCID PMC5886799. https://resolver.caltech.edu/CaltechAUTHORS:20160617-145307431

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Abstract

Photoacoustic computed tomography (PACT) is an emerging computed imaging modality that exploits optical contrast and ultrasonic detection principles to form images of the absorbed optical energy density within tissue. When the imaging system employs conventional piezoelectric ultrasonic transducers, the ideal photoacoustic (PA) signals are degraded by the transducers' acousto-electric impulse responses (EIRs) during the measurement process. If unaccounted for, this can degrade the accuracy of the reconstructed image. In principle, the effect of the EIRs on the measured PA signals can be ameliorated via deconvolution; images can be reconstructed subsequently by application of a reconstruction method that assumes an idealized EIR. Alternatively, the effect of the EIR can be incorporated into an imaging model and implicitly compensated for during reconstruction. In either case, the efficacy of the correction can be limited by errors in the assumed EIRs. In this work, a joint optimization approach to PACT image reconstruction is proposed for mitigating errors in reconstructed images that are caused by use of an inaccurate EIR. The method exploits the bi-linear nature of the imaging model and seeks to refine the measured EIR during the process of reconstructing the sought-after absorbed optical energy density. Computer-simulation and experimental studies are conducted to investigate the numerical properties of the method and demonstrate its value for mitigating image distortions and enhancing the visibility of fine structures.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1109/TMI.2015.2437356DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886799PubMed CentralArticle
http://arxiv.org/abs/1505.07426arXivDiscussion Paper
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2015 IEEE. Manuscript received February 26, 2015; revised April 23, 2015; accepted May 10, 2015. Date of publication June 01, 2015; date of current version November 25, 2015. This work was supported in part by NIH Awards CA1744601 and EB01696301.
Funders:
Funding AgencyGrant Number
NIHCA1744601
NIHEB01696301
Subject Keywords:Iterative image reconstruction, optoacoustic tomography, photoacoustic computed tomography, thermoacoustic tomography, variable projection method
Issue or Number:12
PubMed Central ID:PMC5886799
Record Number:CaltechAUTHORS:20160617-145307431
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160617-145307431
Official Citation:Q. Sheng et al., "A Constrained Variable Projection Reconstruction Method for Photoacoustic Computed Tomography Without Accurate Knowledge of Transducer Responses," in IEEE Transactions on Medical Imaging, vol. 34, no. 12, pp. 2443-2458, Dec. 2015. doi: 10.1109/TMI.2015.2437356
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:68494
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:18 Jun 2016 18:09
Last Modified:03 Oct 2019 10:14

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