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The heme-p53 interaction: Linking iron metabolism to p53 signaling and tumorigenesis

Shen, Jia and Sheng, Xiangpeng and Chang, ZeNan and Wu, Qian and Xie, Dong and Wang, Fudi and Hu, Ronggui (2016) The heme-p53 interaction: Linking iron metabolism to p53 signaling and tumorigenesis. Molecular and Cellular Oncology, 3 (1). Art. No. e965642. ISSN 2372-3556. PMCID PMC4845248. http://resolver.caltech.edu/CaltechAUTHORS:20160620-135337091

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Abstract

Recently, we reported that heme binds to tumor suppressor p53 protein (TP53, best known as p53) and promotes its nuclear export and cytosolic degradation, whereas iron chelation stabilizes p53 protein and suppresses tumors in a p53-dependent manner. This not only provides mechanistic insights into tumorigenesis associated with iron excess, but also helps guide the administration of chemotherapy based on iron deprivation in the clinic.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.4161/23723548.2014.965642DOIArticle
http://www.tandfonline.com/doi/full/10.4161/23723548.2014.965642PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845248/PubMed CentralArticle
Additional Information:© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC© Jia Shen, Xiangpeng Sheng, ZeNan Chang, Qian Wu, Dong Xie, Fudi Wang, and Ronggui Hu. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. Submitted: 08/11/2014; Revised: 08/13/2014; Accepted: 08/13/2014. The authors truly appreciate the support from all collaborators and funding from the Ministry of Science and Technology of China (2010CB912101, 2012CB910800, 2013CB910900, 2011CB915501), the National Natural Science Foundation of China (31270828, 31070678), Chinese Academy of Sciences (Instrument Developing Project YZ201339), Cancer Center of SIBS-Xuhui Central Hospital (CCR2012003), and Shanghai Institute of Neurosciences (SKLN-201206). No potential conflicts of interest were disclosed.
Funders:
Funding AgencyGrant Number
Ministry of Science and Technology (China)2010CB912101
Ministry of Science and Technology (China)2012CB910800
Ministry of Science and Technology (China)2013CB910900
Ministry of Science and Technology (China)2011CB915501
Ministry of Science and Technology (China)31270828
Ministry of Science and Technology (China)31070678
Chinese Academy of SciencesYZ201339
SIBS-Xuhui Central Hospital Cancer CenterCCR2012003
Shanghai Institute of NeurosciencesSKLN-201206
Subject Keywords:heme, p53, iron deprivation, nuclear export, hemochromatosis, tumorigenesis
PubMed Central ID:PMC4845248
Record Number:CaltechAUTHORS:20160620-135337091
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160620-135337091
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:68538
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:21 Jun 2016 23:48
Last Modified:21 Jun 2016 23:48

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