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Validation of sensor for postoperative positioning with intraocular gas

Brodie, Frank L. and Woo, Kelly Y. and Balakrishna, Ashwin and Choo, Hyuck and Grubbs, Robert H. (2016) Validation of sensor for postoperative positioning with intraocular gas. Clinical Ophthalmology, 2016 (10). pp. 955-960. ISSN 1177-5483. PMCID PMC4888728.

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Purpose: Surgical repair of retinal attachment or macular hole frequently requires intraocular gas. This necessitates specific postoperative positioning to improve outcomes and avoid complications. However, patients struggle with correct positioning. We have developed a novel sensor to detect the position of the gas bubble in the eye and provide feedback to patients in real time. In this paper, we determine the specificity and sensitivity of our sensor in vitro using a model eye. Methods: We assessed the reliability of our sensor to detect when a gas bubble has deviated off a model retinal break in a model eye. Various bubble sizes representing the intraocular kinetics of sulfur hexafluoride gas and varying degrees of deviation from the correct position were tested using the sensor attached to a mannequin head with a model eye. Results: We recorded 36 data points. The sensor acted appropriately in 33 (91.7%) of them. The sensor triggered the alarm every time the bubble deviated off the break (n=15, sensitivity =100%). However, it triggered the alarm (falsely) 3/21 times when the bubble was correctly positioned over the retinal break (specificity =86%). Conclusion: Our device shows excellent sensitivity (100%) and specificity (86%) in detecting whether intraocular gas is tamponading a retinal break in a model eye.

Item Type:Article
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URLURL TypeDescription CentralArticle
Choo, Hyuck0000-0002-8903-7939
Grubbs, Robert H.0000-0002-0057-7817
Additional Information:© 2016 Brodie et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms. Received 29 January 2016; Accepted for publication 31 March 2016; Published 25 May 2016. Research support was provided by the That Man May See and Research to Prevent Blindness. Disclosure: A patent has been filed by California Institute of Technology on behalf of the authors; as such there is a potential for financial benefit if this concept is commercialized. The authors report no other conflicts of interest in this work.
Funding AgencyGrant Number
That Man May See FoundationUNSPECIFIED
Research to Prevent BlindnessUNSPECIFIED
Subject Keywords:postoperative positioning, intraocular gas, vitrectomy, retinal detachment, macular hole, pneumatic retinopexy
Issue or Number:10
PubMed Central ID:PMC4888728
Record Number:CaltechAUTHORS:20160620-140450083
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:68539
Deposited By: Tony Diaz
Deposited On:21 Jun 2016 23:44
Last Modified:03 Oct 2019 10:14

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