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Frequency-swept time-reversed ultrasonically encoded optical focusing

Suzuki, Yuta and Wang, Lihong V. (2014) Frequency-swept time-reversed ultrasonically encoded optical focusing. Applied Physics Letters, 105 (19). Art. No. 191108. ISSN 0003-6951. PMCID PMC4235623. doi:10.1063/1.4901955.

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A technique to rapidly scan an optical focus inside a turbid medium is attractive for various biomedical applications. Time-reversed ultrasonically encoded (TRUE) optical focusing has previously demonstrated light focusing into a turbid medium, using both analog and digital devices. Although the digital implementation can generate a focus with high energy, it has been time consuming to scan the TRUE focus inside a sample. Here, by sweeping the frequencies of both ultrasound and light, we demonstrate a multiplex recording of ultrasonically encoded wavefronts, accelerating the generation of multiple TRUE foci. Using this technique, we obtained a 2-D image of a fluorescent target centered inside a turbid sample having a thickness of 2.4 transport mean free paths.

Item Type:Article
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URLURL TypeDescription CentralArticle
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2014 AIP Publishing LLC. Received 14 September 2014; accepted 5 November 2014; published online 11 November 2014. We thank J. Ballard and J. W. Tay for editing the manuscript. This work was sponsored in part by National Institutes of Health grants DP1 EB016986 (NIH Director's Pioneer Award). L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.
Funding AgencyGrant Number
NIHDP1 EB016986
Issue or Number:19
PubMed Central ID:PMC4235623
Record Number:CaltechAUTHORS:20160622-084430679
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Official Citation:Frequency-swept time-reversed ultrasonically encoded optical focusing Suzuki, Yuta and Wang, Lihong V., Applied Physics Letters, 105, 191108 (2014), DOI:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:68564
Deposited By: Tony Diaz
Deposited On:23 Jun 2016 03:36
Last Modified:11 Nov 2021 04:01

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