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Optical-resolution photoacoustic endomicroscopy in vivo

Yang, Joon-Mo and Li, Chiye and Chen, Ruimin and Rao, Bin and Yao, Junjie and Yeh, Cheng-Hung and Danielli, Amos and Maslov, Konstantin and Zhou, Qifa and Shung, K. Kirk and Wang, Lihong V. (2015) Optical-resolution photoacoustic endomicroscopy in vivo. Biomedical Optics Express, 6 (3). pp. 918-932. ISSN 2156-7085. PMCID PMC4361445.

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Optical-resolution photoacoustic microscopy (OR-PAM) has become a major experimental tool of photoacoustic tomography, with unique imaging capabilities for various biological applications. However, conventional imaging systems are all table-top embodiments, which preclude their use in internal organs. In this study, by applying the OR-PAM concept to our recently developed endoscopic technique, called photoacoustic endoscopy (PAE), we created an optical-resolution photoacoustic endomicroscopy (OR-PAEM) system, which enables internal organ imaging with a much finer resolution than conventional acoustic-resolution PAE systems. OR-PAEM has potential preclinical and clinical applications using either endogenous or exogenous contrast agents.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Chen, Ruimin0000-0002-5338-359X
Rao, Bin0000-0001-6494-3110
Maslov, Konstantin0000-0003-3408-8840
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2015 Optical Society of America. Received 10 Dec 2014; revised 26 Jan 2015; accepted 28 Jan 2015; published 23 Feb 2015. We thank Prof. James Ballard for his attentive reading of the manuscript. This work was sponsored in part by National Institutes of Health grants R01 CA157277, DP1 EB016986 (NIH Director’s Pioneer Award), P41-EB002182, and R01 CA186567 (NIH Director’s Transformative Research Award). L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work. K.M. has a financial interest in Microphotoacoustics, Inc.
Funding AgencyGrant Number
NIHR01 CA157277
NIHDP1 EB016986
NIHR02 CA186567
Issue or Number:3
Classification Code:OCIS codes: (170.0170) Medical optics and biotechnology; (170.3880) Medical and biological imaging; (170.3890) Medical optics instrumentation; (170.5120) Photoacoustic imaging; (170.2150) Endoscopic imaging; (170.0180) Microscopy
PubMed Central ID:PMC4361445
Record Number:CaltechAUTHORS:20160622-102632287
Persistent URL:
Official Citation:Joon-Mo Yang, Chiye Li, Ruimin Chen, Bin Rao, Junjie Yao, Cheng-Hung Yeh, Amos Danielli, Konstantin Maslov, Qifa Zhou, K. Kirk Shung, and Lihong V. Wang, "Optical-resolution photoacoustic endomicroscopy in vivo," Biomed. Opt. Express 6, 918-932 (2015)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:68577
Deposited By: Tony Diaz
Deposited On:23 Jun 2016 01:08
Last Modified:09 Mar 2020 13:19

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