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High-speed photoacoustic tomography

Song, Liang and Guo, Zijian and Wang, Lihong V. (2014) High-speed photoacoustic tomography. In: Advanced biophotonics: tissue optical sectioning. Taylor & Francis , Boca Raton, FL, pp. 423-447. ISBN 978-1-4398-9581-8.

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Traditional diagnostic imaging technologies—including ultrasound, x-ray computed tomography, and magnetic resonance imaging—have dramatically improved patient care in the clinic. However, these technologies still have limited ability to detect small lesions. In most cases, the detectable lesions are ~1 cm in dimeter, corresponding to ~10^9 cells (including circulating and microscopic metastatic deposits) and representing ~2/3 of the natural history of a cancer [1]. Consequently, the window of opportunity for treatment before a tumor reaches its lethal state is narrow. Hence, it is imperative to develop novel technologies capable of detecting neoplasia early. Non ionizing biomedical optical imaging is highly desirable because of its rich contrast. In particular, optical absorption—to which photoacoustic tomography is sensitive—can be used to obtain physiological parameters such as the total concentration and oxygenation of hemoglobin is related to hyper-metabolism. Since both angiogenesis and hypermetabolism are hallmarks of cancer, photoacoustic tomography can potentially provide early-cancer detection.

Item Type:Book Section
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Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2014 Taylor & Francis Group, LLC.
Record Number:CaltechAUTHORS:20160622-110515374
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:68583
Deposited By: Tony Diaz
Deposited On:23 Jun 2016 00:36
Last Modified:11 Nov 2021 04:02

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