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Quantitative Analysis of the Fate of Gold Nanocages In Vitro and In Vivo after Uptake by U87-MG Tumor Cells

Cho, Eun Chul and Zhang, Yu and Cai, Xin and Moran, Christine M. and Wang, Lihong V. and Xia, Younan (2013) Quantitative Analysis of the Fate of Gold Nanocages In Vitro and In Vivo after Uptake by U87-MG Tumor Cells. Angewandte Chemie International Edition, 52 (4). pp. 1152-1155. ISSN 1433-7851. PMCID PMC3730258. http://resolver.caltech.edu/CaltechAUTHORS:20160622-140553425

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Abstract

Not always equal: When a mother cell that contains Au nanocages divides, the nanoparticles are unequally distributed between the two daughter cells. This unequal distribution of nanoparticles as well as their clearance from the cells (see picture) is quantitatively analyzed both in vitro and in vivo using two-photon microscopy and photoacoustic microscopy, respectively.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/anie.201208096DOIArticle
http://onlinelibrary.wiley.com/doi/10.1002/anie.201208096/abstractPublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730258PubMed CentralArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Alternate Title:A Quantitative Analysis of the Fate of Au Nanocages after Uptake by U87-MG Tumor Cells under Both in vitro and in vivo Conditions
Additional Information:© 2013 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Received: October 8, 2012; Published online: December 6, 2012. This study was supported in part by a grant from NIH (R01 CA138527) and startup funds from Washington University in St. Louis (to Y.X.), and NIH Grants R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, and 5P60 DK02057933 (to L.V.W.). Part of the research was conducted at the Alafi Neuroimaging Laboratory, the Hope Center for Neurological Disorders (NIH Neuroscience Blueprint Center Core Grant P30 NS057105).
Funders:
Funding AgencyGrant Number
NIHR01 CA138527
Washington UniversityUNSPECIFIED
NIHR01 EB000712
NIHR01 EB008085
NIHR01 CA134539
NIHU54 CA136398
NIH5P60 DK02057933
NIHP30 NS057105
Subject Keywords:biological activity; cell uptake; drug delivery; gold; nanoparticles
PubMed Central ID:PMC3730258
Record Number:CaltechAUTHORS:20160622-140553425
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160622-140553425
Official Citation:Cho, E. C., Zhang, Y., Cai, X., Moran, C. M., Wang, L. V. and Xia, Y. (2013), Quantitative Analysis of the Fate of Gold Nanocages In Vitro and In Vivo after Uptake by U87-MG Tumor Cells . Angew. Chem. Int. Ed., 52: 1152–1155. doi:10.1002/anie.201208096
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:68598
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:23 Jun 2016 00:11
Last Modified:23 Jun 2016 00:11

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