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An apertureless near-field microscope for fluorescence imaging

Yang, T. J. and Lessard, Guillaume A. and Quake, Stephen R. (2000) An apertureless near-field microscope for fluorescence imaging. Applied Physics Letters, 76 (3). pp. 378-380. ISSN 0003-6951. http://resolver.caltech.edu/CaltechAUTHORS:YANapl00

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Abstract

We describe an apertureless near field microscope for imaging fluorescent samples. Optical contrast is generated by exploiting fluorescent quenching near a metallized atomic force microscope tip. This microscope has been used to image fluorescent latex beads with subdiffraction limit resolution. The use of fluorescence allows us to prove that the contrast mechanism is indeed spectroscopic in origin.


Item Type:Article
Additional Information:©2000 American Institute of Physics. (Received 18 August 1999; accepted 16 November 1999) The authors thank Pierre Barritault and Francisco Guzman for contributions in the early stages of this work and Jeff Kimble for the generous loan of equipment. This work was supported in part by the Keck Foundation. G.L. had partial financial support from the Fonds FCAR.
Subject Keywords:near-field scanning optical microscopy; optical microscopes; fluorescence; image resolution; dyes; biological techniques
Record Number:CaltechAUTHORS:YANapl00
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:YANapl00
Alternative URL:http://dx.doi.org10.1063/1.125759
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:6860
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:29 Dec 2006
Last Modified:26 Dec 2012 09:26

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