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Biomimetic Accommodating Intraocular Lens Using a Valved Deformable Liquid Balloon

DeBoer, Charles M. T. and Lee, Jonathan K. and Wheelan, Brooks P. and Cable, Craig and Shi, Wendian and Tai, Yu-Chong and Humayun, Mark S. (2016) Biomimetic Accommodating Intraocular Lens Using a Valved Deformable Liquid Balloon. IEEE Transactions on Biomedical Engineering, 63 (6). pp. 1129-1135. ISSN 0018-9294. doi:10.1109/TBME.2015.2484379.

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Objective: Presbyopia is a common age-related condition that prevents people from focusing on near objects. The etiology of presbyopia continues to be debated, but the end effect of all postulated mechanisms is the lack of deformation of the human lens. Using our understanding of the biomechanical properties of the natural human lens, we created a unique accommodating intraocular lens. Although this lens can be used for lenticular disease such as myopia and hyperoperopia, this study addresses the needs of cataract patients with presbyopia. Methods: The lens was implanted into presbyopic human cadaver eyes. Focal length of the lens was measured with simulated muscle contraction. Lens dimensions were measured using artificial tissue and a finite-element analysis (FEA) to simulate accommodation. Lens power was measured at various fill volumes. Accelerated soak testing for an equivalent of 7.4 years was performed and lens weight and optical transmittance were measured. Results: Previously presbyopic human eyes were able to accommodate between 2.0 and 7.4 diopters after lens implantation. FEA and lens measurements demonstrated a change in curvature of the anterior and posterior portions of the lens during accommodation. After accelerated aging, lens weight remained unchanged and optical transmission was 96%. Lens power increased with fill volume. Conclusion: A deformable liquid lens reversed presbyopia, can be individualized by optically adjusting for each patient, is stable for long periods of time, and is compatible with minimally invasive surgical techniques. Significance: A deformable liquid-filled lens can significantly improve accommodation over the presbyopic natural lens.

Item Type:Article
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Tai, Yu-Chong0000-0001-8529-106X
Humayun, Mark S.0000-0002-5830-5208
Additional Information:© 2015 IEEE. Manuscript received June 14, 2015; revised September 16, 2015; accepted September 23, 2015. Date of publication September 30, 2015; date of current version May 18, 2016. This work was supported in part by a research grant from Alcon. C. DeBoer, B. Wheelan, J. Lee, C. Cable, and W. Shi work with the same company, which has licensed patents related to this work. In addition, we would like to thank T. Roper in the Caltech MEMS cleanroom, as well as the MEMS cleanroom members, including M. Nandra and H. Wan Do. M. McCormick helped with mold design and mold manufacturing. In addition, we are grateful for the surgical guidance we received from the many surgeons who helped with this project, including R. Ribeiro, J.-C. Martinez, J.-C. Gutierrez, R. Lopez, A. Oregon, and W. Charafeddin, and T. M. Soe for the schematic of the inflated lens.
Funding AgencyGrant Number
Subject Keywords:Accommodating intraocular lens, implant, microelectromechanical systems, micromachining, optics, presbyopia
Issue or Number:6
Record Number:CaltechAUTHORS:20160624-130219973
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Official Citation:C. M. T. DeBoer et al., "Biomimetic Accommodating Intraocular Lens Using a Valved Deformable Liquid Balloon," in IEEE Transactions on Biomedical Engineering, vol. 63, no. 6, pp. 1129-1135, June 2016. doi: 10.1109/TBME.2015.2484379
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:68662
Deposited By: Tony Diaz
Deposited On:24 Jun 2016 20:25
Last Modified:11 Nov 2021 04:03

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