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Femtonewton Force Spectroscopy of Single Extended DNA Molecules

Meiners, Jens-Christian and Quake, Stephen R. (2000) Femtonewton Force Spectroscopy of Single Extended DNA Molecules. Physical Review Letters, 84 (21). pp. 5014-5017. ISSN 0031-9007. doi:10.1103/PhysRevLett.84.5014.

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We studied the thermal fluctuations of single DNA molecules with a novel optical tweezer based force spectroscopy technique. This technique combines femtonewton sensitivity with millisecond time resolution, surpassing the sensitivity of previous force measurements in aqueous solution with comparable bandwidth by a hundredfold. Our data resolve long-standing questions concerning internal hydrodynamics of the polymer and anisotropy in the molecular relaxation times and friction coefficients. The dynamics at high extension show interesting nonlinear behavior.

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Additional Information:©2000 The American Physical Society Received 27 December 1999 This work was supported by the National Science Foundation CAREER program.
Issue or Number:21
Record Number:CaltechAUTHORS:MEIprl00
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:6875
Deposited By: Archive Administrator
Deposited On:30 Dec 2006
Last Modified:08 Nov 2021 20:37

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