Meiners, Jens-Christian and Quake, Stephen R. (2000) Femtonewton Force Spectroscopy of Single Extended DNA Molecules. Physical Review Letters, 84 (21). pp. 5014-5017. ISSN 0031-9007. doi:10.1103/PhysRevLett.84.5014. https://resolver.caltech.edu/CaltechAUTHORS:MEIprl00
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Abstract
We studied the thermal fluctuations of single DNA molecules with a novel optical tweezer based force spectroscopy technique. This technique combines femtonewton sensitivity with millisecond time resolution, surpassing the sensitivity of previous force measurements in aqueous solution with comparable bandwidth by a hundredfold. Our data resolve long-standing questions concerning internal hydrodynamics of the polymer and anisotropy in the molecular relaxation times and friction coefficients. The dynamics at high extension show interesting nonlinear behavior.
| Item Type: | Article | ||||||
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| Additional Information: | ©2000 The American Physical Society Received 27 December 1999 This work was supported by the National Science Foundation CAREER program. | ||||||
| Issue or Number: | 21 | ||||||
| DOI: | 10.1103/PhysRevLett.84.5014 | ||||||
| Record Number: | CaltechAUTHORS:MEIprl00 | ||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:MEIprl00 | ||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
| ID Code: | 6875 | ||||||
| Collection: | CaltechAUTHORS | ||||||
| Deposited By: | Archive Administrator | ||||||
| Deposited On: | 30 Dec 2006 | ||||||
| Last Modified: | 08 Nov 2021 20:37 |
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