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Sputum Iron Levels During Cystic Fibrosis Pulmonary Exacerbation: A Longitudinal Study

McCallin, Kyle and Cowley, Elise and Reyes, Maria C. and Van Sambeek, Lindsay and Hunter, Ryan C. and Asfour, Fadi and Newman, Dianne and Kato, Roberta M. (2015) Sputum Iron Levels During Cystic Fibrosis Pulmonary Exacerbation: A Longitudinal Study. American Journal of Respiratory and Critical Care Medicine, 191 . Art. No. A3343. ISSN 1073-449X. https://resolver.caltech.edu/CaltechAUTHORS:20160701-094042706

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Abstract

The airways of patients with cystic fibrosis are frequently colonized with bacteria, particularly Pseudomonas aeruginosa. Repeated pulmonary exacerbations contribute to decline in lung function. Iron is an important cofactor in bacterial growth and biofilm production in Pseudomonas aeruginosa. We demonstrated sputum ferrous iron and Pseudomonas bacterial burden are associated with worse lung function as measured by FEV_1 in cross-sectional studies. Ferrous iron constitutes a greater amount of total iron measured as lung function worsens. We hypothesized that sputum iron will decrease as lung function improves over the course of pulmonary exacerbation.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2015.191.1_MeetingAbstracts.A3343PublisherArticle
ORCID:
AuthorORCID
Van Sambeek, Lindsay0000-0002-7206-7410
Hunter, Ryan C.0000-0003-3841-1676
Newman, Dianne0000-0003-1647-1918
Additional Information:© 2015 American Thoracic Society. This abstract is funded by: Gardner Foundation Grant, Webb Foundation Grant, NIH and HHMI.
Funders:
Funding AgencyGrant Number
Gardner FoundationUNSPECIFIED
Del Webb FoundationUNSPECIFIED
NIHUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Record Number:CaltechAUTHORS:20160701-094042706
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160701-094042706
Official Citation:B52. PEDIATRIC CYSTIC FIBROSIS : pp. A3343-A3343 Sputum Iron Levels During Cystic Fibrosis Pulmonary Exacerbation: A Longitudinal Study First published online May 06, 2015 as doi:10.1164/ajrccm-conference.2015.191.1_MeetingAbstracts.A3343
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:68804
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:06 Jul 2016 02:23
Last Modified:09 Mar 2020 13:19

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