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Noninvasive Photoacoustic Microscopy of Living Cells in Two and Three Dimensions through Enhancement by a Metabolite Dye

Zhang, Yu and Cai, Xin and Wang, Yu and Zhang, Chi and Li, Li and Choi, Sung-Wook and Wang, Lihong V. and Xia, Younan (2011) Noninvasive Photoacoustic Microscopy of Living Cells in Two and Three Dimensions through Enhancement by a Metabolite Dye. Angewandte Chemie International Edition, 50 (32). pp. 7359-7363. ISSN 1433-7851. PMCID PMC3149874. http://resolver.caltech.edu/CaltechAUTHORS:20160701-124434057

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Abstract

A new type of contrast agent, 1-(4,5-dimethyl-2-thiazolyl)-3,5-diphenylformazan (MTT formazan), is reported for nondestructive and nontoxic imaging of living cells by photoacoustic microscopy (see picture). The contrast mechanism is general and can be applied to essentially all types of metabolically active cells, including stem cells and tumor cells.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/anie.201101659DOIArticle
http://onlinelibrary.wiley.com/doi/10.1002/anie.201101659/abstractPublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149874PubMed CentralArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Received: March 8, 2011; Published online: June 16, 2011. This work was supported in part by the NIH Director’s Pioneer Award (DP1 OD000798) and startup funds from Washington University in St. Louis (to Y.X.). This work was also sponsored by grants of the NIH (numbers R01 EB000712, R01 EB008085, and U54 CA136398 to L.V.W.). Part of the research was performed at the Nano Research Facility, a member of the National Nanotechnology Infrastructure Network (NNIN), which is supported by the NSF under award ECS-0335765.
Funders:
Funding AgencyGrant Number
NIHDP1 OD000798
Washington UniversityUNSPECIFIED
NIHR01 EB000712
NIHR01 EB008085
NIHU54 CA136398
NSFECS-0335765
Subject Keywords:cancer; imaging agents; photoacoustic microscopy; tissue engineering
PubMed Central ID:PMC3149874
Record Number:CaltechAUTHORS:20160701-124434057
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160701-124434057
Official Citation:Zhang, Y., Cai, X., Wang, Y., Zhang, C., Li, L., Choi, S.-W., Wang, L. V. and Xia, Y. (2011), Noninvasive Photoacoustic Microscopy of Living Cells in Two and Three Dimensions through Enhancement by a Metabolite Dye. Angew. Chem. Int. Ed., 50: 7359–7363. doi:10.1002/anie.201101659
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:68814
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:06 Jul 2016 02:56
Last Modified:06 Jul 2016 02:56

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