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A Facile Synthesis of Novel Self-Assembled Gold Nanorods Designed for Near-Infrared Imaging

Pan, Dipanjan and Pramanik, Manojit and Senpan, Angana and Wickline, Samuel A. and Wang, Lihong V. and Lanza, Gregory M. (2010) A Facile Synthesis of Novel Self-Assembled Gold Nanorods Designed for Near-Infrared Imaging. Journal of Nanoscience and Nanotechnology, 10 (12). pp. 8118-8123. ISSN 1533-4880. PMCID PMC3096062. http://resolver.caltech.edu/CaltechAUTHORS:20160701-130302347

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Abstract

Molecular imaging techniques now allow recognition of early biochemical, physiological, and anatomical changes before manifestation of gross pathological changes. Photoacoustic imaging represents a novel non-ionizing detection technique that combines the advantages of optical and ultrasound imaging. Noninvasive photoacoustic tomography (PAT) imaging in combination with nanoparticle-based contrast agents show promise in improved detection and diagnosis of cardiovascular and cancer related diseases. In this report, a novel strategy is introduced to achieve self-assembled colloidal gold nanorods, which are constrained to the vasculature. Gold nanorods (2–4 nm) were incorporated into the core of self-assembled lipid-encapsulated nanoparticles (sGNR) (∼130 nm), providing more than hundreds of gold atoms per nanoparticle of 20% colloid suspension. The physico-chemical characterization in solution and anhydrous state with analytical techniques demonstrated that the particles were spherical and highly mono dispersed. In addition to the synthesis and characterization, sensitive near-infrared photoacoustic detection was impressively demonstrated in vitro.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1166/jnn.2010.3034DOIArticle
http://www.ingentaconnect.com/content/asp/jnn/2010/00000010/00000012/art00030PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096062PubMed CentralArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2010 American Scientific Publishers. The financial support from the AHA under grant number 0835426N (Dipanjan Pan), from NIH under grant numbers NS059302, CA119342 (Gregory M. Lanza), HL073646 (Samuel A. Wickline), U54 CA136398, R01EB000712, R01NS046214, EB008085 (Lihong V. Wang) is greatly appreciated. Lihong V. Wang has a financial interest in Microphotoacoustic, Inc. and Endra, Inc., which, however, did not support this work.
Funders:
Funding AgencyGrant Number
American Heart Association0835426N
NIHNS059302
NIHCA119342
NIHHL073646
NIHU54 CA136398
NIHR01EB000712
NIHR01NS046214
NIHEB008085
Subject Keywords:Photoacoustic Tomography; Nanobeacons; Gold Nanorod; Surface Plasmon Resonance; Near Infrared Imaging
PubMed Central ID:PMC3096062
Record Number:CaltechAUTHORS:20160701-130302347
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160701-130302347
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:68815
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:06 Jul 2016 02:55
Last Modified:06 Jul 2016 02:55

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