Stroehlein, Andreas J. and Young, Neil D. and Hall, Ross S. and Korhonen, Pasi K. and Hofmann, Andreas and Sternberg, Paul W. and Jabbar, Abdul and Gasser, Robin B. (2016) CAP protein superfamily members in Toxocara canis. Parasites and Vectors, 9 (1). Art. No. 360. ISSN 1756-3305. PMCID PMC4921028. doi:10.1186/s13071-016-1642-y. https://resolver.caltech.edu/CaltechAUTHORS:20160706-100101575
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Abstract
Background: Proteins of the cysteine-rich secretory proteins, antigen 5 and pathogenesis-related 1 (CAP) superfamily are recognized or proposed to play roles in parasite development and reproduction, and in modulating host immune attack and infection processes. However, little is known about these proteins for most parasites. Results: In the present study, we explored CAP proteins of Toxocara canis, a socioeconomically important zoonotic roundworm. To do this, we mined and curated transcriptomic and genomic data, predicted and curated full-length protein sequences (n = 28), conducted analyses of these data and studied the transcription of respective genes in different developmental stages of T. canis. In addition, based on information available for Caenorhabditis elegans, we inferred that selected genes (including lon-1, vap-1, vap-2, scl-1, scl-8 and scl-11 orthologs) of T. canis and their interaction partners likely play central roles in this parasite’s development and/or reproduction via TGF-beta and/or insulin-like signaling pathways, or via host interactions. Conclusion: In conclusion, this study could provide a foundation to guide future studies of CAP proteins of T. canis and related parasites, and might assist in finding new interventions against diseases caused by these parasites.
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| Additional Information: | © 2016 The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Received: 2 May 2016. Accepted: 13 June 2016. Published: 24 June 2016. Support from the Victorian Life Sciences Computation Initiative, Australia (VLSCI; grant no. VR0007) on its Peak Computing Facility at the University of Melbourne, Australia, an initiative of the Victorian Government, Australia, is gratefully acknowledged (RBG), as is other support from the Medicines for Malaria Venture (MMV), YourGene Bioscience (Taiwan) and Melbourne Water (RBG). We acknowledge the contributions of all of the staff members at WormBase (www.wormbase.org). The present study was funded by the Australian Research Council (ARC), the National Health and Medical Research Council of Australia (NHMRC) and the Wellcome Trust (Pathfinder) (RBG). NDY is a NHMRC Career Development Fellow (CDF). AJS is a recipient of a Melbourne International Research Scholarship (MIRS) and a Melbourne International Fee Remission Scholarship (MIFRS) from The University of Melbourne. Funding bodies had no role in the design of the study or collection, analysis or interpretation of data, or in writing the manuscript. Availability of data and material: The datasets supporting the conclusions of this article are included within the article and the additional file. Authors’ contributions: Conceived and designed the study and supervised the project: AJS and RBG. Undertook the study and data analysis: AJS and RSH. Contributed to analysis using various tools: NDY and PKK. Wrote the paper: AJS and RBG. Contributed to the interpretation of findings, drafting of the manuscript and funding: NDY, AJ, AH, PWS and RBG. All authors read and approved the final version of the manuscript. The authors declare that they have no competing interests. Consent for publication: Not applicable. Ethics approval and consent to participate: Not applicable. | ||||||||||||
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| Subject Keywords: | Nematodes, Toxocara canis, CAP (SCP/TAPS) protein genes, Transcription profiles, Genetic interactions | ||||||||||||
| Issue or Number: | 1 | ||||||||||||
| PubMed Central ID: | PMC4921028 | ||||||||||||
| DOI: | 10.1186/s13071-016-1642-y | ||||||||||||
| Record Number: | CaltechAUTHORS:20160706-100101575 | ||||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20160706-100101575 | ||||||||||||
| Official Citation: | CAP protein superfamily members in Toxocara canis Andreas J. Stroehlein, Neil D. Young, Ross S. Hall, Pasi K. Korhonen, Andreas Hofmann, Paul W. Sternberg, Abdul Jabbar and Robin B. Gasser Parasites & Vectors 2016 9:360 DOI: 10.1186/s13071-016-1642-y | ||||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||
| ID Code: | 68852 | ||||||||||||
| Collection: | CaltechAUTHORS | ||||||||||||
| Deposited By: | Ruth Sustaita | ||||||||||||
| Deposited On: | 07 Jul 2016 18:51 | ||||||||||||
| Last Modified: | 11 Nov 2021 04:05 |
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