CaltechAUTHORS
  A Caltech Library Service

Effects of Photoacoustic Imaging and Photothermal Ablation Therapy Mediated by Targeted Hollow Gold Nanospheres in an Orthotopic Mouse Xenograft Model of Glioma

Lu, Wei and Melancon, Marites P. and Xiong, Chiyi and Huang, Qian and Elliott, Andrew and Song, Shaoli and Zhang, Rui and Flores, Leo G., II and Gelovani, Juri G. and Wang, Lihong V. and Ku, Geng and Stafford, R. Jason and Li, Chun (2011) Effects of Photoacoustic Imaging and Photothermal Ablation Therapy Mediated by Targeted Hollow Gold Nanospheres in an Orthotopic Mouse Xenograft Model of Glioma. Cancer Research, 71 (19). pp. 6116-6121. ISSN 0008-5472. PMCID PMC3185126. https://resolver.caltech.edu/CaltechAUTHORS:20160708-083655411

[img] PDF - Accepted Version
See Usage Policy.

1488Kb

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20160708-083655411

Abstract

Advancements in nanotechnology have made it possible to create multifunctional nanostructures that can be used simultaneously to image and treat cancers. For example, hollow gold nanospheres (HAuNS) have been shown to generate intense photoacoustic signals and induce efficient photothermal ablation (PTA) therapy. In this study, we used photoacoustic tomography, a hybrid imaging modality, to assess the intravenous delivery of HAuNS targeted to integrins that are overexpressed in both glioma and angiogenic blood vessels in a mouse model of glioma. Mice were then treated with near-infrared laser, which elevated tumor temperature by 20.7°C. We found that PTA treatment significantly prolonged the survival of tumor-bearing mice. Taken together, these results show the feasibility of using a single nanostructure for image-guided local tumor PTA therapy with photoacoustic molecular imaging.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1158/0008-5472.CAN-10-4557DOIArticle
http://cancerres.aacrjournals.org/content/71/19/6116PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185126PubMed CentralArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2011 by the American Association for Cancer Research. Received December 18, 2010; revised July 6, 2011; accepted August 8, 2011; published OnlineFirst August 19, 2011. We thank Stephanie Deming for editing the manuscript. This work was supported in part by grants from the NIH (grant R01 CA119387 05 S1 and MD Anderson Cancer Center Support Grant CA016672), the John S. Dunn Foundation, SPORE Head and Neck Career Development Award P50CA097007 (M.P. Melancon), and an Odyssey Fellowship (M.P. Melancon). Funding as an Odyssey Fellow is supported by the Odyssey Program and The Cockrell Foundation Award for Scientific Achievement at the University of Texas MD Anderson Cancer Center. The Cu-64 was provided by Washington University Medical School, which is partially funded by National Cancer Institute grant R24 CA86307. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. No potential conflicts of interest were disclosed.
Funders:
Funding AgencyGrant Number
NIHR01 CA119387 05 S1
NIHCA016672
John S. Dunn FoundationUNSPECIFIED
NIHP50CA097007
Odyssey ProgramUNSPECIFIED
University of TexasUNSPECIFIED
National Cancer InstituteR24 CA86307
Cockrell FoundationUNSPECIFIED
Issue or Number:19
PubMed Central ID:PMC3185126
Record Number:CaltechAUTHORS:20160708-083655411
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160708-083655411
Official Citation:Effects of Photoacoustic Imaging and Photothermal Ablation Therapy Mediated by Targeted Hollow Gold Nanospheres in an Orthotopic Mouse Xenograft Model of Glioma Wei Lu, Marites P. Melancon, Chiyi Xiong, Qian Huang, Andrew Elliott, Shaoli Song, Rui Zhang, Leo G. Flores, Juri G. Gelovani, Lihong V. Wang, Geng Ku, R. Jason Stafford, Chun Li Cancer Res Oct 2011 (71) (19) 6116-6121; DOI: 10.1158/0008-5472.CAN-10-4557
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:68910
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:09 Jul 2016 18:19
Last Modified:03 Oct 2019 10:17

Repository Staff Only: item control page