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A 3-D High-Frequency Array Based 16 Channel Photoacoustic Microscopy System for In Vivo Micro-Vascular Imaging

Bitton, Rachel and Zemp, Roger and Yen, Jesse and Wang, Lihong V. and Shung, K. Kirk (2009) A 3-D High-Frequency Array Based 16 Channel Photoacoustic Microscopy System for In Vivo Micro-Vascular Imaging. IEEE Transactions on Medical Imaging, 28 (8). pp. 1190-1197. ISSN 0278-0062. PMCID PMC2757099. https://resolver.caltech.edu/CaltechAUTHORS:20160708-094211580

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Abstract

This paper discusses the design of a novel photoacoustic microscopy imaging system with promise for studying the structure of tissue microvasculature for applications in visualizing angiogenesis. A new 16 channel analog and digital high-frequency array based photoacoustic microscopy system (PAM) was developed using an Nd: YLF pumped tunable dye laser, a 30 MHz piezo composite linear array transducer, and a custom multichannel receiver electronics system. Using offline delay and sum beam- forming and beamsteering, phantom images were obtained from a 6 µm carbon fiber in water at a depth of 8 mm. The measured -6 dB lateral and axial spatial resolution of the system was 100 ± 5 µm and 45 ± 5 µm, respectively. The dynamic focusing capability of the system was demonstrated by imaging a composite carbon fiber matrix through a 12.5 mm imaging depth. Next, 2-D in vivo images were formed of vessels around 100 µm in diameter in the human hand. Three-dimensional in vivo images were also formed of micro-vessels 3 mm below the surface of the skin in two Sprague Dawley rats.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1109/TMI.2008.2011899DOIArticle
http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=4738385PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757099PubMed CentralArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2009 IEEE. Manuscript received April 01, 2008; revised September 25, 2008. First published January 06, 2009; current version published July 29, 2009. This work was supported in part by the National Institute of Health under Grant R01 EB000712 and Grant P41-EB2182. The authors would like to thank J. M. Cannata for his work in the design and fabrication of the high-frequency transducer array.
Funders:
Funding AgencyGrant Number
NIHR01 EB000712
NIHP41-EB2182
Subject Keywords:High-frequency ultrasound, multichannel receiver electronics, photoacoustic imaging, transducer array
Issue or Number:8
PubMed Central ID:PMC2757099
Record Number:CaltechAUTHORS:20160708-094211580
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160708-094211580
Official Citation:R. Bitton, R. Zemp, J. Yen, L. V. Wang and K. K. Shung, "A 3-D High-Frequency Array Based 16 Channel Photoacoustic Microscopy System for In Vivo Micro-Vascular Imaging," in IEEE Transactions on Medical Imaging, vol. 28, no. 8, pp. 1190-1197, Aug. 2009. doi: 10.1109/TMI.2008.2011899
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:68915
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:09 Jul 2016 05:10
Last Modified:03 Oct 2019 10:17

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