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Photoacoustic microscopy in tissue engineering

Cai, Xin and Zhang, Yu Shrike and Xia, Younan and Wang, Lihong V. (2013) Photoacoustic microscopy in tissue engineering. Materials Today, 16 (3). pp. 67-77. ISSN 1369-7021 . PMCID PMC3678877.

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Photoacoustic tomography (PAT) is an attractive modality for noninvasive, volumetric imaging of scattering media such as biological tissues. By choosing the ultrasonic detection frequency, PAT enables scalable spatial resolution with an imaging depth of up to ∼7 cm while maintaining a high depth-to-resolution ratio of ∼200 and consistent optical absorption contrasts. Photoacoustic microscopy (PAM), the microscopic embodiment of PAT, aims to image at millimeter depth and micrometer-scale resolution. PAM is well-suited for characterizing three-dimensional scaffold-based samples, including scaffolds themselves, cells, and blood vessels, both qualitatively and quantitatively. Here we review our previous work on applications of PAM in tissue engineering and then discuss its future developments.

Item Type:Article
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URLURL TypeDescription CentralArticle
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2013 Elsevier Ltd. Open access under CC BY-NC-ND license. Available online 24 April 2013. We are grateful to Sandra Matteucci for close reading of the manuscript. Our work was supported in part by an NIH Director's Pioneer Award (DP1 OD000798) and startup funds from Georgia Institute of Technology (to Y.X.). Our work was also sponsored by NIH grants R01 EB000712, R01 EB008085, R01 CA140220, R01 CA157277, R01 CA159959, U54 CA136398, and DP1 EB016986 – NIH Director's Pioneer Award (to L.V.W.). L.V.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work. Others claim no competing financial interests.
Funding AgencyGrant Number
NIHDP1 OD000798
Georgia Institute of TechnologyUNSPECIFIED
NIHR01 EB000712
NIHR01 EB008085
NIHR01 CA140220
NIHR01 CA157277
NIHR01 CA159959
NIHU54 CA136398
NIHDP1 EB016986
PubMed Central ID:PMC3678877
Record Number:CaltechAUTHORS:20160711-124717717
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Official Citation:Xin Cai, Yu Shrike Zhang, Younan Xia, Lihong V. Wang, Photoacoustic microscopy in tissue engineering, Materials Today, Volume 16, Issue 3, March 2013, Pages 67-77, ISSN 1369-7021, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:68962
Deposited By: Tony Diaz
Deposited On:28 Jul 2016 18:03
Last Modified:28 Jul 2016 18:03

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