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Amplitude-masked photoacoustic wavefront shaping and application in flowmetry

Tay, Jian Wei and Liang, Jinyang and Wang, Lihong V. (2014) Amplitude-masked photoacoustic wavefront shaping and application in flowmetry. Optics Letters, 39 (19). pp. 5499-5502. ISSN 0146-9592. PMCID PMC4217128. https://resolver.caltech.edu/CaltechAUTHORS:20160713-110713188

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Abstract

Optical-resolution photoacoustic flowmetry (PAF) allows noninvasive single-cell flow measurements. However, its operational depth is limited by optical diffusion, which prevents focusing beyond shallow depths in scattering media, as well as reducing the measurement signal-to-noise ratio (SNR). To overcome this limitation, we used binary-amplitude wavefront shaping to enhance light focusing in the presence of scattering. Here, the transmission modes that contributed constructively to the intensity at the optical focus were identified and selectively illuminated, resulting in a 14-fold intensity increase and a corresponding increase in SNR. This technique can potentially extend the operational depth of optical-resolution PAF beyond 1 mm in tissue.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1364/OL.39.005499DOIArticle
https://www.osapublishing.org/ol/abstract.cfm?uri=ol-39-19-5499PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217128PubMed CentralArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2014 Optical Society of America. Received March 7, 2014; revised July 11, 2014; accepted August 6, 2014; posted August 20, 2014 (Doc. ID 207834); published September 17, 2014. We would like to thank Yong Zhou for experimental assistance and Prof. James Ballard for assistance in proofreading the manuscript. This work was sponsored in part by the National Institutes of Health grants DP1 EB016986 (Director’s Pioneer Award), R01 CA186567 (Director’s Transformative Research Award), R01 CA157277, and R01 CA159959. L. V. Wang has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which did not support this work.
Funders:
Funding AgencyGrant Number
NIHDP1 EB016986
NIHR01 CA186567
NIHR01 CA157277
NIHR01 CA159959
Issue or Number:19
PubMed Central ID:PMC4217128
Record Number:CaltechAUTHORS:20160713-110713188
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160713-110713188
Official Citation:J. Tay, J. Liang, and L. Wang, "Amplitude-masked photoacoustic wavefront shaping and application in flowmetry," Opt. Lett. 39, 5499-5502 (2014)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69003
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:28 Jul 2016 17:50
Last Modified:03 Oct 2019 10:18

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