Yang, Joon-Mo and Li, Chiye and Chen, Ruimin and Zhou, Qifa and Shung, K. Kirk and Wang, Lihong V. (2014) Catheter-based photoacoustic endoscope. Journal of Biomedical Optics, 19 (6). Art. No. 066001. ISSN 1083-3668. PMCID PMC4041025. http://resolver.caltech.edu/CaltechAUTHORS:20160713-130137719
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Abstract
We report a flexible shaft-based mechanical scanning photoacoustic endoscopy (PAE) system that can be potentially used for imaging the human gastrointestinal tract via the instrument channel of a clinical video endoscope. The development of such a catheter endoscope has been an important challenge to realize the technique’s benefits in clinical settings. We successfully implemented a prototype PAE system that has a 3.2-mm diameter and 2.5-m long catheter section. As the instrument’s flexible shaft and scanning tip are fully encapsulated in a plastic catheter, it easily fits within the 3.7-mm diameter instrument channel of a clinical video endoscope. Here, we demonstrate the intra-instrument channel workability and in vivo animal imaging capability of the PAE system.
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| Additional Information: | © 2014 SPIE. Paper 140033R received Jan. 20, 2014; revised manuscript received Apr. 26, 2014; accepted for publication May 6, 2014; published online Jun. 2, 2014. The authors thank Professor James Ballard for his attentive reading of the paper and Dr. Konstantin Maslov for useful discussions on the system design. The authors also thank Lisa Andrews-Kaminsky and Jenny Kalishman for helping with the animal experiment. This work was sponsored in part by National Institutes of Health Grants Nos. R01 CA157277, DP1 EB016986 (NIH Director’s Pioneer Award), R01 EB016963, and R01 CA159959. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work. | ||||||||||||
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| Subject Keywords: | photoacoustic endoscopy; flexible shaft; catheter endoscope; instrument channel; gastrointestinal endoscopy; rabbit esophagus; in vivo imaging | ||||||||||||
| PubMed Central ID: | PMC4041025 | ||||||||||||
| Record Number: | CaltechAUTHORS:20160713-130137719 | ||||||||||||
| Persistent URL: | http://resolver.caltech.edu/CaltechAUTHORS:20160713-130137719 | ||||||||||||
| Official Citation: | Yang J, Li C, Chen R, Zhou Q, Shung K, Wang LV; Catheter-based photoacoustic endoscope. J. Biomed. Opt. 0001;19(6):066001. doi:10.1117/1.JBO.19.6.066001 | ||||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||
| ID Code: | 69006 | ||||||||||||
| Collection: | CaltechAUTHORS | ||||||||||||
| Deposited By: | Tony Diaz | ||||||||||||
| Deposited On: | 27 Jul 2016 16:19 | ||||||||||||
| Last Modified: | 17 Nov 2017 00:51 |
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