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Genetic Dissection of the Drosophila Nervous System by means of Mosaics

Hotta, Yoshiki and Benzer, Seymour (1970) Genetic Dissection of the Drosophila Nervous System by means of Mosaics. Proceedings of the National Academy of Sciences of the United States of America, 67 (3). pp. 1156-1163. ISSN 0027-8424. PMCID PMC283331. https://resolver.caltech.edu/CaltechAUTHORS:HOTpnas70

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Abstract

Given a mutant having abnormal behavior, the anatomical domain responsible for the deficit may be identified by the use of genetic mosaicism. Individuals may be produced in which a portion of the body is mutant male while the rest is normal female. In such sex mosaics, or gynandromorphs, the division line between normal and mutant parts can occur in various orientations. Mutants of five different genes (cistrons) on the X-chromosome of Drosophila melanogaster, having various abnormalities in visual function, have been tested by this method. All of these have been found to be autonomous, i.e., a mutant eye always functions abnormally, regardless of the amount of normal tissue present elsewhere, indicating that the primary causes of the behavioral deficits in these mutants are within the eye.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://dx.doi.org/10.1073/pnas.67.3.1156DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC283331/PubMed CentralArticle
http://www.pnas.org/cgi/content/abstract/67/3/1156OtherUNSPECIFIED
http://www.pnas.org/cgi/content/abstract/67/3/1156OtherUNSPECIFIED
Additional Information:© 1970 by the National Academy of Sciences Communicated August 25, 1970 This work was supported by grant GB-8293 from the National Science Foundation. We are indebted to Dr. John R. Merriam for advice and stimulating discussion on the genetics and development of gynandromorphs, and to Lydia Yuan for histological studies.
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Funding AgencyGrant Number
NSFGB-8293
Issue or Number:3
PubMed Central ID:PMC283331
Record Number:CaltechAUTHORS:HOTpnas70
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:HOTpnas70
Official Citation:Genetic Dissection of the Drosophila Nervous System by Means of Mosaics Yoshiki Hotta, Seymour Benzer Proceedings of the National Academy of Sciences Nov 1970, 67 (3) 1156-1163; DOI: 10.1073/pnas.67.3.1156
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:6901
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:01 Jan 2007
Last Modified:02 Oct 2019 23:37

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