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Handheld photoacoustic microscopy to detect melanoma depth in vivo

Zhou, Yong and Xing, Wenxin and Maslov, Konstantin I. and Cornelius, Lynn A. and Wang, Lihong V. (2014) Handheld photoacoustic microscopy to detect melanoma depth in vivo. Optics Letters, 39 (16). pp. 4731-4734. ISSN 0146-9592. PMCID PMC4160823. http://resolver.caltech.edu/CaltechAUTHORS:20160713-152848418

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Abstract

We developed handheld photoacoustic microscopy (PAM) to detect melanoma and determine tumor depth in nude mice in vivo. Compared to our previous PAM system for melanoma imaging, a new light delivery mechanism is introduced to improve light penetration. We show that melanomas with 4.1 and 3.7 mm thicknesses can be successfully detected in phantom and in in vivo experiments, respectively. With its deep melanoma imaging ability and handheld design, this system can be tested for clinical melanoma diagnosis, prognosis, and surgical planning for patients at the bedside.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1364/OL.39.004731DOIArticle
https://www.osapublishing.org/ol/abstract.cfm?uri=ol-39-16-4731PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160823PubMed CentralArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2014 Optical Society of America. Received May 23, 2014; accepted June 13, 2014; posted June 24, 2014 (Doc. ID 212688); published August 6, 2014. The authors would like to thank Prof. James Ballard for manuscript editing. This work was sponsored in part by National Institutes of Health grants DP1 EB016986 (NIH Director’s Pioneer Award), R01 CA186567 (NIH Director’s Transformative Research Award), R01 EB016963, and R01 CA159959. L. W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work. K. M. has a financial interest in Microphotoacoustics, Inc.
Funders:
Funding AgencyGrant Number
NIHDP1 EB016986
NIHR01 CA186567
NIHR01 EB016963
NIHR01 CA159959
Classification Code:OCIS codes: (170.5120) Photoacoustic imaging; (170.3880) Medical and biological imaging; (170.3890) Medical optics instrumentation
PubMed Central ID:PMC4160823
Record Number:CaltechAUTHORS:20160713-152848418
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160713-152848418
Official Citation:Yong Zhou, Wenxin Xing, Konstantin I. Maslov, Lynn A. Cornelius, and Lihong V. Wang, "Handheld photoacoustic microscopy to detect melanoma depth in vivo," Opt. Lett. 39, 4731-4734 (2014)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69014
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:28 Jul 2016 17:57
Last Modified:28 Jul 2016 17:57

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