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Handheld photoacoustic tomography probe built using optical-fiber parallel acoustic delay lines

Cho, Young and Chang, Cheng-Chung and Yu, Jaesok and Jeon, Mansik and Kim, Chulhong and Wang, Lihong V. and Zou, Jun (2014) Handheld photoacoustic tomography probe built using optical-fiber parallel acoustic delay lines. Journal of Biomedical Optics, 19 (8). Art. No. 086007. ISSN 1083-3668. PMCID PMC4407766. doi:10.1117/1.JBO.19.8.086007.

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The development of the first miniaturized parallel acoustic delay line (PADL) probe for handheld photoacoustic tomography (PAT) is reported. Using fused-silica optical fibers with low acoustic attenuation, we constructed two arrays of eight PADLs. Precision laser micromachining was conducted to produce robust and accurate mechanical support and alignment structures for the PADLs, with minimal acoustic distortion and interchannel coupling. The 16 optical-fiber PADLs, each with a different time delay, were arranged to form one input port and two output ports. A handheld PADL probe was constructed using two single-element transducers and two data acquisition channels (equal to a channel reduction ratio of 8:1). Photoacoustic (PA) images of a black-ink target embedded in an optically scattering phantom were successfully acquired. After traveling through the PADLs, the eight channels of differently time-delayed PA signals reached each single-element ultrasonic transducer in a designated nonoverlapping time series, allowing clear signal separation for PA image reconstruction. Our results show that the PADL technique and the handheld probe can potentially enable real-time PAT, while significantly reducing the complexity and cost of the ultrasound receiver system.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Wang, Lihong V.0000-0001-9783-4383
Zou, Jun0000-0002-9543-6135
Additional Information:© 2014 SPIE. Paper 140087R received Feb. 13, 2014; revised manuscript received Jun. 30, 2014; accepted for publication Jul. 14, 2014; published online Aug. 7, 2014. This work was supported in part by a grant (CMMI-1131758) from the National Science Foundation to J.Z., a grant (U54-CA136398) from the National Institutes of Health to L.V. W., and by MSIP (Ministry of Science, ICT, and Future Planning), Korea, under the “IT Consilience Creative Program” (NIPA-2013-H0203-13-1001) supervised by the NIPA (National IT Industry Promotion Agency) and NRF grant of Korea government (MSIP) (2011-0030075) to C.K. L. V. Wang has a financial interest in Microphotoacoustics, Inc., and in Endra, Inc., which, however, did not support this work.
Funding AgencyGrant Number
Ministry of Science, ICT, and Future Planning (Korea)NIPA-2013-H0203-13-1001
National Research Foundation of Korea2011-0030075
Subject Keywords:handheld probe; photoacoustic tomography; parallel acoustic delay line; real time
Issue or Number:8
PubMed Central ID:PMC4407766
Record Number:CaltechAUTHORS:20160713-155306524
Persistent URL:
Official Citation:Cho Y, Chang C, Yu J, et al; Handheld photoacoustic tomography probe built using optical-fiber parallel acoustic delay lines. J. Biomed. Opt. 0001;19(8):086007. doi:10.1117/1.JBO.19.8.086007
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69015
Deposited By: Tony Diaz
Deposited On:28 Jul 2016 17:36
Last Modified:11 Nov 2021 04:08

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