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A Thermodynamic-Based Interpretation of Protein Expression Heterogeneity in Different Glioblastoma Multiforme Tumors Identifies Tumor-Specific Unbalanced Processes

Kravchenko-Balasha, Nataly and Johnson, Hannah and White, Forest M. and Heath, James R. and Levine, R. D. (2016) A Thermodynamic-Based Interpretation of Protein Expression Heterogeneity in Different Glioblastoma Multiforme Tumors Identifies Tumor-Specific Unbalanced Processes. Journal of Physical Chemistry B, 120 (26). pp. 5990-5997. ISSN 1520-6106. PMCID PMC4937832. https://resolver.caltech.edu/CaltechAUTHORS:20160714-113801517

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Abstract

We describe a thermodynamic-motivated, information theoretic analysis of proteomic data collected from a series of 8 glioblastoma multiforme (GBM) tumors. GBMs are considered here as prototypes of heterogeneous cancers. That heterogeneity is viewed here as manifesting in different unbalanced biological processes that are associated with thermodynamic-like constraints. The analysis yields a molecular description of a stable steady state that is common across all tumors. It also resolves molecular descriptions of unbalanced processes that are shared by several tumors, such as hyperactivated phosphoprotein signaling networks. Further, it resolves unbalanced processes that provide unique classifiers of tumor subgroups. The results of the theoretical interpretation are compared against those of statistical multivariate methods and are shown to provide a superior level of resolution for identifying unbalanced processes in GBM tumors. The identification of specific constraints for each GBM tumor suggests tumor-specific combination therapies that may reverse this imbalance.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1021/acs.jpcb.6b01692DOIArticle
https://pubs.acs.org/doi/suppl/10.1021/acs.jpcb.6b01692PublisherSupporting Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937832PubMed CentralArticle
ORCID:
AuthorORCID
Heath, James R.0000-0001-5356-4385
Alternate Title:A Thermodynamic Based Interpretation of Protein Expression Heterogeneity in Different GBM Tumors Identifies Tumor Specific Unbalanced Processes
Additional Information:© 2016 American Chemical Society. Special Issue: William M. Gelbart Festschrift. Received: February 23, 2016. Revised: March 28, 2016. Published: April 1, 2016. This work was supported by an EMBO postdoctoral fellowship to N.K.B.; by a European Commission FP7 Future and Emerging Technologies−Open Project BAMBI 618024 (to R.D.L.); and by the National Cancer Institute (1U54 CA199090-01 JRH PI), the Ben and Catherine Ivy Foundation (J.R.H.), and the Jean Perkins Foundation (J.R.H. PI).
Funders:
Funding AgencyGrant Number
European Molecular Biology Organization (EMBO)UNSPECIFIED
European Research Council (ERC)BAMBI 618024
National Cancer Institute1U54 CA199090-01 JRH PI
Ben and Catherine Ivy FoundationUNSPECIFIED
Jean Perkins FoundationUNSPECIFIED
Issue or Number:26
PubMed Central ID:PMC4937832
Record Number:CaltechAUTHORS:20160714-113801517
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160714-113801517
Official Citation: A Thermodynamic-Based Interpretation of Protein Expression Heterogeneity in Different Glioblastoma Multiforme Tumors Identifies Tumor-Specific Unbalanced Processes Nataly Kravchenko-Balasha, Hannah Johnson, Forest M. White, James R. Heath, and R. D. Levine The Journal of Physical Chemistry B 2016 120 (26), 5990-5997 DOI: 10.1021/acs.jpcb.6b01692
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69031
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:14 Jul 2016 19:45
Last Modified:18 Dec 2019 23:55

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