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In vivo optically encoded photoacoustic flowgraphy

Zhang, Ruiying and Wang, Lidai and Yao, Junjie and Yeh, Cheng-Hung and Wang, Lihong V. (2014) In vivo optically encoded photoacoustic flowgraphy. Optics Letters, 39 (13). pp. 3814-3817. ISSN 0146-9592. PMCID PMC4165860.

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We present an optically encoded photoacoustic (PA) flow imaging method based on optical-resolution PA microscopy. An intensity-modulated continuous-wave laser photothermally encodes the flowing medium, and a pulsed laser generates PA waves to image the encoded heat pattern. Flow speeds can be calculated by cross correlation. The method was validated in phantoms at flow speeds ranging from 0.23 to 11  mm/s. Venous blood flow speed in a mouse ear was also measured.

Item Type:Article
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URLURL TypeDescription CentralArticle
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2014 Optical Society of America. Received March 17, 2014; accepted April 13, 2014; posted May 16, 2014 (Doc. ID 208239); published June 20, 2014. The authors would like to thank Dr. Konstantin Maslov for helpful discussions and experimental assistance. The authors would also like to thank Prof. James Ballard for his close reading of the manuscript. This research was supported by the National Institutes of Health Grants DP1 EB016986 (NIH Director’s Pioneer Award), R01 CA134539, and R01 CA159959. L. V. W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.
Funding AgencyGrant Number
NIHDP1 EB016986
NIHR01 CA134539
NIHR01 CA159959
Issue or Number:13
Classification Code:OCIS codes: (170.5120) Photoacoustic imaging; (140.6810) Thermal effects; (110.6820) Thermal imaging; (120.7250) Velocimetry
PubMed Central ID:PMC4165860
Record Number:CaltechAUTHORS:20160720-081950398
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Official Citation:Ruiying Zhang, Lidai Wang, Junjie Yao, Cheng-Hung Yeh, and Lihong V. Wang, "In vivo optically encoded photoacoustic flowgraphy," Opt. Lett. 39, 3814-3817 (2014)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69124
Deposited By: Tony Diaz
Deposited On:26 Jul 2016 23:44
Last Modified:03 Oct 2019 10:19

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