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Photoacoustic brain imaging: from microscopic to macroscopic scales

Yao, Junjie and Wang, Lihong V. (2014) Photoacoustic brain imaging: from microscopic to macroscopic scales. Neurophotonics, 1 (1). Art. No. 011003. ISSN 2329-423X. PMCID PMC4232215.

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Human brain mapping has become one of the most exciting contemporary research areas, with major breakthroughs expected in the coming decades. Modern brain imaging techniques have allowed neuroscientists to gather a wealth of anatomic and functional information about the brain. Among these techniques, by virtue of its rich optical absorption contrast, high spatial and temporal resolutions, and deep penetration, photoacoustic tomography (PAT) has attracted more and more attention, and is playing an increasingly important role in brain studies. In particular, PAT complements other brain imaging modalities by providing high-resolution functional and metabolic imaging. More importantly, PAT’s unique scalability enables scrutinizing the brain at both microscopic and macroscopic scales, using the same imaging contrast. In this review, we present the state-of-the-art PAT techniques for brain imaging, summarize representative neuroscience applications, outline the technical challenges in translating PAT to human brain imaging, and envision potential technological deliverables.

Item Type:Article
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URLURL TypeDescription CentralArticle
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2014 The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. Paper 14018VSSR received Feb. 27, 2014; revised manuscript received Mar. 28, 2014; accepted for publication Mar. 31, 2014; published online May 28, 2014. The authors appreciate professor James Ballard’s close reading of the paper, and Yu Zhang and professor Younan Xia (Georgia Institute of Technology) for providing the cultured neuron sample in Figs. 2(a) and 2(b). This work was sponsored by NIH Grants DP1 EB016986 (NIH Director’s Pioneer Award), R01 CA186567 (NIH Director’s Transformative Research Award), R01 EB016963, R01 CA134539, R01 EB010049, R01 CA157277, and R01 CA159959. L.V. Wang has a financial interest in Endra, Inc., and Microphotoacoustics, Inc., which, however, did not support this work.
Funding AgencyGrant Number
NIHDP1 EB016986
NIHR01 CA186567
NIHR01 EB016963
NIHR01 CA134539
NIHR01 EB010049
NIHR01 CA157277
NIHR01 CA159959
Subject Keywords:photoacoustic tomography; photoacoustic microscopy; optical absorption contrast; deep brain imaging; functional imaging; molecular imaging; metabolic imaging
Issue or Number:1
PubMed Central ID:PMC4232215
Record Number:CaltechAUTHORS:20160720-134806700
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Official Citation:Yao J, Wang LV; Photoacoustic brain imaging: from microscopic to macroscopic scales. Neurophoton. 0001;1(1):011003. doi:10.1117/1.NPh.1.1.011003
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69138
Deposited By: Tony Diaz
Deposited On:25 Jul 2016 22:43
Last Modified:03 Oct 2019 10:19

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