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Synthetic Peptides from Four Separate Regions of the Poliovirus Type 1 Capsid Protein VP1 Induce Neutralizing Antibodies

Chow, M. and Yabrov, R. and Bittle, J. and Hogle, J. and Baltimore, D. (1985) Synthetic Peptides from Four Separate Regions of the Poliovirus Type 1 Capsid Protein VP1 Induce Neutralizing Antibodies. Proceedings of the National Academy of Sciences of the United States of America, 82 (3). pp. 910-914. ISSN 0027-8424. PMCID PMC397157.

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Peptides from different regions of the poliovirus type 1 capsid protein VP1 were synthesized. Antibodies raised against these peptides in rabbits and rats recognized the cognate peptides and denatured VP1. Peptides from four regions of VP1 generated antisera with neutralizing titers specifically against poliovirus type 1. Antisera against all other regions of VP1 failed to neutralize virus infectivity, although some of the antisera clearly bound to native virions. Thus, the neutralizing determinants on VP1 reside in specific noncontiguous regions of the protein and can be defined by specific peptides from these regions.

Item Type:Article
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Baltimore, D.0000-0001-8723-8190
Additional Information:© 1985 by the National Academy of Sciences Contributed by David Baltimore, September 17, 1984 We thank R. Lerner, H. Alexander, P. Worrel, and P. Safer for both technical advice and helpful discussions throughout the course of this study. This work was supported by a grant from the National Institute of Allergy and Infectious Diseases. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.
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Subject Keywords:poliovirus type 1 Mahoney strain; biotin immunoblots; host immune response
Issue or Number:3
PubMed Central ID:PMC397157
Record Number:CaltechAUTHORS:CHOpnas85
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:6915
Deposited By: Archive Administrator
Deposited On:02 Jan 2007
Last Modified:15 Jun 2020 21:34

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