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Absolute photoacoustic thermometry in deep tissue

Yao, Junjie and Ke, Haixin and Tai, Stephen and Zhou, Yong and Wang, Lihong V. (2013) Absolute photoacoustic thermometry in deep tissue. Optics Letters, 38 (24). pp. 5228-5231. ISSN 0146-9592. PMCID PMC3901074. doi:10.1364/OL.38.005228.

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Photoacoustic thermography is a promising tool for temperature measurement in deep tissue. Here we propose an absolute temperature measurement method based on the dual temperature dependences of the Grüneisen parameter and the speed of sound in tissue. By taking ratiometric measurements at two adjacent temperatures, we can eliminate the factors that are temperature irrelevant but difficult to correct for in deep tissue. To validate our method, absolute temperatures of blood-filled tubes embedded ∼9  mm deep in chicken tissue were measured in a biologically relevant range from 28°C to 46°C. The temperature measurement accuracy was ∼0.6°C. The results suggest that our method can be potentially used for absolute temperature monitoring in deep tissue during thermotherapy.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2013 Optical Society of America. Received August 27, 2013; accepted October 19, 2013; posted October 28, 2013 (Doc. ID 196384); published December 3, 2013. The authors appreciate Prof. James Ballard’s close reading of the manuscript. We thank Lidai Wang and Arie Krumholz for helpful discussions. This work was sponsored by NIH grants DP1 EB016986 (NIH Director’s Pioneer Award), R01 EB008085, R01 CA134539, U54 CA136398, R01 CA157277, and R01 CA159959. L. V. Wang has a financial interest in Endra, Inc., and Microphotoacoustics, Inc., which, however, did not support this work.
Funding AgencyGrant Number
NIHDP1 EB016986
NIHR01 EB008085
NIHR01 CA134539
NIHU54 CA136398
NIHR01 CA157277
NIHR01 CA159959
Issue or Number:24
Classification Code:OCIS codes: (170.5120) Photoacoustic imaging; (120.6780) Temperature
PubMed Central ID:PMC3901074
Record Number:CaltechAUTHORS:20160726-120523415
Persistent URL:
Official Citation:Junjie Yao, Haixin Ke, Stephen Tai, Yong Zhou, and Lihong V. Wang, "Absolute photoacoustic thermometry in deep tissue," Opt. Lett. 38, 5228-5231 (2013)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69225
Deposited By: Tony Diaz
Deposited On:26 Jul 2016 19:16
Last Modified:11 Nov 2021 04:11

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