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Comparison Study of Gold Nanohexapods, Nanorods, and Nanocages for Photothermal Cancer Treatment

Wang, Yucai and Black, Kvar C. L. and Luehmann, Hannah and Li, Weiyang and Zhang, Yu and Cai, Xin and Wan, Dehui and Liu, Si-Yun and Li, Max and Kim, Paul and Li, Zhi-Yuan and Wang, Lihong V. and Liu, Yongjian and Xia, Younan (2013) Comparison Study of Gold Nanohexapods, Nanorods, and Nanocages for Photothermal Cancer Treatment. ACS Nano, 7 (3). pp. 2068-2077. ISSN 1936-0851. PMCID PMC3609935. doi:10.1021/nn304332s.

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Gold nanohexapods represent a novel class of optically tunable nanostructures consisting of an octahedral core and six arms grown on its vertices. By controlling the length of the arms, their localized surface plasmon resonance peaks could be tuned from the visible to the near-infrared region for deep penetration of light into soft tissues. Herein we compare the in vitro and in vivo capabilities of Au nanohexapods as photothermal transducers for theranostic applications by benchmarking against those of Au nanorods and nanocages. While all these Au nanostructures could absorb and convert near-infrared light into heat, Au nanohexapods exhibited the highest cellular uptake and the lowest cytotoxicity in vitro for both the as-prepared and PEGylated nanostructures. In vivo pharmacokinetic studies showed that the PEGylated Au nanohexapods had significant blood circulation and tumor accumulation in a mouse breast cancer model. Following photothermal treatment, substantial heat was produced in situ and the tumor metabolism was greatly reduced for all these Au nanostructures, as determined with ^(18)F-flourodeoxyglucose positron emission tomography/computed tomography (^(18)F-FDG PET/CT). Combined together, we can conclude that Au nanohexapods are promising candidates for cancer theranostics in terms of both photothermal destruction and contrast-enhanced diagnosis.

Item Type:Article
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URLURL TypeDescription Information CentralArticle
Zhang, Yu0000-0001-8938-1927
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2013 American Chemical Society. Received for review September 18, 2012 and accepted February 5, 2013. Published online February 6, 2013. This work was supported by a grant from the NCI (R01 CA138527). M.L. was an REU student from Duke University, and he was supported by the NSF NNIN program. We thank the Division of Comparative Medicine Research Animal Diagnostic Laboratory at Washington University School of Medicine for histology analysis. The authors declare no competing financial interest.
Funding AgencyGrant Number
NIHR01 CA138527
Subject Keywords:theranostics; gold nanostructures; near-infrared; photothermal effect; tumor ablation
Issue or Number:3
PubMed Central ID:PMC3609935
Record Number:CaltechAUTHORS:20160726-152910222
Persistent URL:
Official Citation:Comparison Study of Gold Nanohexapods, Nanorods, and Nanocages for Photothermal Cancer Treatment Yucai Wang, Kvar C. L. Black, Hannah Luehmann, Weiyang Li, Yu Zhang, Xin Cai, Dehui Wan, Si-Yun Liu, Max Li, Paul Kim, Zhi-Yuan Li, Lihong V. Wang, Yongjian Liu, and Younan Xia ACS Nano 2013 7 (3), 2068-2077 DOI: 10.1021/nn304332s
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69231
Deposited By: Tony Diaz
Deposited On:26 Jul 2016 22:43
Last Modified:11 Nov 2021 04:11

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