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Enhancement of photoacoustic tomography by ultrasonic computed tomography based on optical excitation of elements of a full-ring transducer array

Xia, Jun and Huang, Chao and Maslov, Konstantin and Anastasio, Mark A. and Wang, Lihong V. (2013) Enhancement of photoacoustic tomography by ultrasonic computed tomography based on optical excitation of elements of a full-ring transducer array. Optics Letters, 38 (16). pp. 3140-3143. ISSN 0146-9592. PMCID PMC3884569. https://resolver.caltech.edu/CaltechAUTHORS:20160727-093707118

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Abstract

Photoacoustic computed tomography (PACT) is a hybrid technique that combines optical excitation and ultrasonic detection to provide high-resolution images in deep tissues. In the image reconstruction, a constant speed of sound (SOS) is normally assumed. This assumption, however, is often not strictly satisfied in deep tissue imaging, due to acoustic heterogeneities within the object and between the object and the coupling medium. If these heterogeneities are not accounted for, they will cause distortions and artifacts in the reconstructed images. In this Letter, we incorporated ultrasonic computed tomography (USCT), which measures the SOS distribution within the object, into our full-ring array PACT system. Without the need for ultrasonic transmitting electronics, USCT was performed using the same laser beam as for PACT measurement. By scanning the laser beam on the array surface, we can sequentially fire different elements. As a first demonstration of the system, we studied the effect of acoustic heterogeneities on photoacoustic vascular imaging. We verified that constant SOS is a reasonable approximation when the SOS variation is small. When the variation is large, distortion will be observed in the periphery of the object, especially in the tangential direction.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1364/OL.38.003140DOIArticle
https://www.osapublishing.org/ol/abstract.cfm?uri=ol-38-16-3140PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884569PubMed CentralArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2013 Optical Society of America. Received July 11, 2013; accepted July 22, 2013; posted July 25, 2013 (Doc. ID 193722); published August 14, 2013. The authors appreciate Prof. James Ballard’s close reading of the manuscript. This work was sponsored in part by National Institutes of Health grants DP1 EB016986 (NIH Director’s Pioneer Award), R01 EB016963, R01 EB008085, R01 CA134539, U54 CA136398, R01 CA157277, and R01 CA159959. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work. K.M. has a financial interest in Microphotoacoustics, Inc., which, however, did not support this work.
Funders:
Funding AgencyGrant Number
NIHDP1 EB016986
NIHR01 EB016963
NIHR01 EB016963
NIHR01 EB008085
NIHR01 CA134539
NIHU54 CA136398
NIHR01 CA157277
NIHR01 CA159959
Issue or Number:16
Classification Code:OCIS codes: (110.5120) Photoacoutic imaging; (110.6960) Tomography; (170.3010) Image reconstruction techniques; (170.5120) Photoacoustic imaging; (170.7170) Ultrasound
PubMed Central ID:PMC3884569
Record Number:CaltechAUTHORS:20160727-093707118
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160727-093707118
Official Citation:Jun Xia, Chao Huang, Konstantin Maslov, Mark A. Anastasio, and Lihong V. Wang, "Enhancement of photoacoustic tomography by ultrasonic computed tomography based on optical excitation of elements of a full-ring transducer array," Opt. Lett. 38, 3140-3143 (2013)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69239
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:27 Jul 2016 16:46
Last Modified:03 Oct 2019 10:20

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