Britten, Roy J. and Davidson, Eric H. (1969) Gene Regulation for Higher Cells: A Theory. Science, 165 (3891). pp. 349-357. ISSN 0036-8075. doi:10.1126/science.165.3891.349. https://resolver.caltech.edu/CaltechAUTHORS:20160727-100412965
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Abstract
Cell differentiation is based almost certainly on the regulation of gene activity, so that for each state of differentiation a certain set of genes is active in transcription and other genes are inactive. The establishment of this concept (1) has depended on evidence indicating that the cells of an organism generally contain identical genomes (2). Direct support for the idea that regulation of gene activity underlies cell differentiation comes from evidence that much of the genome in higher cell types is inactive (3) and that different ribonucleic acids (RNA) are synthesized in different cell types (4).
| Item Type: | Article | |||||||||
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| Additional Information: | © 1969 American Association for the Advancement of Science. | |||||||||
| Issue or Number: | 3891 | |||||||||
| DOI: | 10.1126/science.165.3891.349 | |||||||||
| Record Number: | CaltechAUTHORS:20160727-100412965 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20160727-100412965 | |||||||||
| Official Citation: | Gene Regulation for Higher Cells: A Theory By Roy J. Britten, Eric H. Davidson Science 25 Jul 1969: Vol. 165, Issue 3891, pp. 349-357 DOI: 10.1126/science.165.3891.349 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 69243 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Ruth Sustaita | |||||||||
| Deposited On: | 27 Jul 2016 18:41 | |||||||||
| Last Modified: | 11 Nov 2021 04:11 |
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