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Gene Regulation for Higher Cells: A Theory

Britten, Roy J. and Davidson, Eric H. (1969) Gene Regulation for Higher Cells: A Theory. Science, 165 (3891). pp. 349-357. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20160727-100412965

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Abstract

Cell differentiation is based almost certainly on the regulation of gene activity, so that for each state of differentiation a certain set of genes is active in transcription and other genes are inactive. The establishment of this concept (1) has depended on evidence indicating that the cells of an organism generally contain identical genomes (2). Direct support for the idea that regulation of gene activity underlies cell differentiation comes from evidence that much of the genome in higher cell types is inactive (3) and that different ribonucleic acids (RNA) are synthesized in different cell types (4).


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.165.3891.349DOIArticle
http://science.sciencemag.org/content/165/3891/349.shortPublisherArticle
Additional Information:© 1969 American Association for the Advancement of Science.
Issue or Number:3891
Record Number:CaltechAUTHORS:20160727-100412965
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160727-100412965
Official Citation:Gene Regulation for Higher Cells: A Theory By Roy J. Britten, Eric H. Davidson Science 25 Jul 1969: Vol. 165, Issue 3891, pp. 349-357 DOI: 10.1126/science.165.3891.349
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69243
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:27 Jul 2016 18:41
Last Modified:03 Oct 2019 10:20

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