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A Model for the Mechanism of Enzyme Induction

Roberts, R. B. and Britten, R. J. and McClure, F. T. (1961) A Model for the Mechanism of Enzyme Induction. Biophysical Journal, 1 (8). pp. 649-656. ISSN 0006-3495. PMCID PMC1366359. doi:10.1016/S0006-3495(61)86914-2.

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A sequence of reactions is postulated from which are derived equations describing the time course of enzyme induction. The model also yields the observed effect of the inducer concentration on the time constant and final rate of enzyme synthesis. Features of the model are: (a) The inducer acts first to release the protein forming template from its site of synthesis on the gene. (b) The inducer is involved again in the equilibrium dissociation of the free template-inducer complex which is utilized in the synthesis of the enzyme-forming unit. (c) The final enzyme-forming unit is unstable and must be synthesized continuously to maintain enzyme synthesis.

Item Type:Article
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URLURL TypeDescription CentralArticle
Additional Information:© 1961 Biophysical Society.
Issue or Number:8
PubMed Central ID:PMC1366359
Record Number:CaltechAUTHORS:20160727-131627307
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Official Citation:Roberts, R. B., Britten, R. J., & McClure, F. T. (1961). A Model for the Mechanism of Enzyme Induction. Biophysical Journal, 1(8), 649–656.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69250
Deposited By: Ruth Sustaita
Deposited On:27 Jul 2016 20:28
Last Modified:11 Nov 2021 04:11

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