McCarthy, B. J. and Britten, R. J. (1962) The Synthesis of Ribosomes in E. coli. I. The Incorporation of C^(14)-Uracil into the Metabolic Pool and RNA. Biophysical Journal, 2 (1). pp. 35-47. ISSN 0006-3495. PMCID PMC1366387. doi:10.1016/S0006-3495(62)86839-8. https://resolver.caltech.edu/CaltechAUTHORS:20160727-134712765
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Abstract
C^(14)-uracil is rapidly incorporated by E. coli at low concentrations. Approximately half the radioactivity passes directly into RNA with very little delay. The remaining half enters a large metabolic pool and later is incorporated into RNA. The total rate of uptake (growing cells) is not greater than the requirement for uracil and cytosine for RNA synthesis. The size of the metabolic pool is not influenced measurably by the external uracil concentration. No evidence is found for the existence of a fraction of RNA which is rapidly synthesized and degraded.
| Item Type: | Article | |||||||||
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| Additional Information: | © 1962 Biophysical Society. Received for publication, August 22, 1961. | |||||||||
| Issue or Number: | 1 | |||||||||
| PubMed Central ID: | PMC1366387 | |||||||||
| DOI: | 10.1016/S0006-3495(62)86839-8 | |||||||||
| Record Number: | CaltechAUTHORS:20160727-134712765 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20160727-134712765 | |||||||||
| Official Citation: | Mccarthy, B. J., & Britten, R. J. (1962). The Synthesis of Ribosomes in E. coli: I. The Incorporation of C14-Uracil into the Metabolic Pool and RNA. Biophysical Journal, 2(1), 35–47. | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 69254 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Ruth Sustaita | |||||||||
| Deposited On: | 27 Jul 2016 20:55 | |||||||||
| Last Modified: | 11 Nov 2021 04:11 |
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