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A Comparison of the Initial Actions of Spleen Deoxyrihonuclease and Pancreatic Deoxyrihonuclease

Young, Elton T., II and Sinsheimer, Robert L. (1965) A Comparison of the Initial Actions of Spleen Deoxyrihonuclease and Pancreatic Deoxyrihonuclease. Journal of Biological Chemistry, 240 (3). pp. 1274-1280. ISSN 0021-9258. http://resolver.caltech.edu/CaltechAUTHORS:20160728-080533751

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Abstract

The modes of action of several deoxyribonucleases have been studied in varying detail. The manner in which pancreatic deoxyribonuclease degrades deoxyribonucleic acid has been thoroughly analyzed both with regard to the breakdown of secondary structure and to the products formed. The activities of several other deoxyribonucleases have been characterized, especially those from Escherichia coli. A variety of specificities has been observed in which the preference seems to be most directly related to the secondary structure of the substrate and not rigorously to the internucleotide linkage.


Item Type:Article
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http://www.jbc.org/content/240/3/1274.shortPublisherArticle
Additional Information:© 1965 American Society for Biochemistry and Molecular Biology. Received for publication, September 2, 1964. These studies were supported in part by Grant RG6965 from the United States Public Health Service. Predoctoral fellow of the National Science Foundation during part of these studies. We would like to thank Dr. Jean Weigle for his help in the culture and assay of λ-phage.
Funders:
Funding AgencyGrant Number
U.S. Public Health Service (USPHS)RG6965
NSF Predoctoral FellowshipUNSPECIFIED
Record Number:CaltechAUTHORS:20160728-080533751
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160728-080533751
Official Citation:Elton T. Young II and Robert L. Sinsheimer A Comparison of the Initial Actions of Spleen Deoxyribonuclease and Pancreatic Deoxyribonuclease J. Biol. Chem. 1965 240: 1274-.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69268
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:28 Jul 2016 18:55
Last Modified:28 Jul 2016 18:55

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