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Cellular identity at the single-cell level

Coskun, Ahmet F. and Eser, Umut and Islam, Saiful (2016) Cellular identity at the single-cell level. Molecular BioSystems, 12 (10). pp. 2965-2979. ISSN 1742-206X. doi:10.1039/c6mb00388e.

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A single cell creates surprising heterogeneity in a multicellular organism. While every organismal cell shares almost an identical genome, molecular interactions in cells alter the use of DNA sequences to modulate the gene of interest for specialization of cellular functions. Each cell gains a unique identity through molecular coding across the DNA, RNA, and protein conversions. On the other hand, loss of cellular identity leads to critical diseases such as cancer. Most cell identity dissection studies are based on bulk molecular assays that mask differences in individual cells. To probe cell-to-cell variability in a population, we discuss single cell approaches to decode the genetic, epigenetic, transcriptional, and translational mechanisms for cell identity formation. In combination with molecular instructions, the physical principles behind cell identity determination are examined. Deciphering and reprogramming cellular types impact biology and medicine.

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Coskun, Ahmet F.0000-0002-5797-1524
Additional Information:© 2016 The Royal Society of Chemistry. Received 18 May 2016, Accepted 18 Jul 2016, First published online 19 Jul 2016. A. F. C. is supported by a Career Award at the Scientific Interface from the Burroughs Wellcome Fund. The authors thank Sten Linnarsson for help with figures.
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Burroughs Wellcome FundUNSPECIFIED
Issue or Number:10
Record Number:CaltechAUTHORS:20160801-084612949
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Official Citation:Cellular identity at the single-cell level Ahmet F. Coskun, Umut Eser and Saiful Islam Mol. BioSyst., 2016,12, 2965-2979 DOI: 10.1039/C6MB00388E
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69344
Deposited By: Tony Diaz
Deposited On:01 Aug 2016 18:18
Last Modified:11 Nov 2021 04:12

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