CaltechAUTHORS
  A Caltech Library Service

Sequence organization in animal DNA and a speculation on hnRNA as a coordinate regulatory transcript

Davidson, Eric H. and Klein, William H. and Britten, Roy J. (1977) Sequence organization in animal DNA and a speculation on hnRNA as a coordinate regulatory transcript. Developmental Biology, 55 (1). pp. 69-84. ISSN 0012-1606. http://resolver.caltech.edu/CaltechAUTHORS:20160802-115919217

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item: http://resolver.caltech.edu/CaltechAUTHORS:20160802-115919217

Abstract

The proposal is made that hnRNA is a coordinate regulatory transcript consisting principally of repetitive regulatory sequences and single-copy spacer sequences. The large transcription units characteristic of animal cells are interpreted as mechanisms for ensuring transcription of multiple regulatory signals under the control of single initiation sites. This organization of transcription is conceived to be a part of the system which integrates the control of gene expression. Animal DNA sequence organization is considered in this light and various consequences of these ideas are explored. Some testable predictions are developed for two cases: (a) that the regulatory signals are diffusible RNA activators originating from the short repetitive sequences interspersed in hnRNA and (b) that the regulatory signals are protein activators coded by message sequences embedded in the hnRNA transcript.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/0012-1606(77)90320-7DOIArticle
http://www.sciencedirect.com/science/article/pii/0012160677903207PublisherArticle
Additional Information:© 1977 Academic Press, Inc. Received 2 July 1976, Accepted 5 August 1976. We would like to thank a number of our colleagues for their careful reading of this manuscript and for their exceedingly useful critical reviews of it. We are particularly indebted in this respect to Professor Norman Davidson of this Institute, Professor David Hogness of Stanford University, and Professor Richard Axel of Columbia University. This work was supported by a grant from the National Institutes of Health, HD-05753.
Funders:
Funding AgencyGrant Number
NIHHD-05753
Record Number:CaltechAUTHORS:20160802-115919217
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160802-115919217
Official Citation:Eric H. Davidson, William H. Klein, Roy J. Britten, Sequence organization in animal DNA and a speculation on hnRNA as a coordinate regulatory transcript, Developmental Biology, Volume 55, Issue 1, January 1977, Pages 69-84, ISSN 0012-1606, http://dx.doi.org/10.1016/0012-1606(77)90320-7. (http://www.sciencedirect.com/science/article/pii/0012160677903207)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69391
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:03 Aug 2016 16:57
Last Modified:03 Aug 2016 16:57

Repository Staff Only: item control page