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Structure of the DNA of bacteriophage φX174. VII. Methylation

Razin, Aharon and Sedat, John W. and Sinsheimer, Robert L. (1970) Structure of the DNA of bacteriophage φX174. VII. Methylation. Journal of Molecular Biology, 53 (2). pp. 251-259. ISSN 0022-2836.

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The only methylated base present in φX174 DNA has been found to be 5-methylcytosine. The number of methyl residues per molecule of φX DNA is estimated to be not more than one. This 5-methylcytosine appears in the φX174 DNA in a non-random distribution; it is found almost exclusively in the dinucleotide fraction of the pyrimidine isopliths, and as judged by its electrophoretic characteristics, the sequence of the 5-methylcytosine containing dinucleotide is either p-m^5C-p-T-p or p-T-p-m^5C-p.

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Additional Information:© 1970 Elsevier Ltd. Received 30 March 1970. This research was supported in part by a grant from the U.S. Public Health Service GM-13554 and a postdoctoral research fellowship 1F05-TW-1348 to one of us (A.R.). The participation of Dr Rolf Knippers in the very early stages of this work and the skillful technical assistance of Miss Alma Shafer are very much appreciated.
Funding AgencyGrant Number
U.S. Public Health Service (USPHS)GM-13554
NIH Postdoctoral Fellowship1F05-TW-1348-01
Issue or Number:2
Record Number:CaltechAUTHORS:20160802-150703422
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Official Citation:Aharon Razin, John W. Sedat, Robert L. Sinsheimer, Structure of the DNA of bacteriophage φX174: VII. Methylation, Journal of Molecular Biology, Volume 53, Issue 2, 28 October 1970, Pages 251-254, IN9-IN11, 255-259, ISSN 0022-2836, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69399
Deposited By: Ruth Sustaita
Deposited On:03 Aug 2016 16:42
Last Modified:03 Oct 2019 10:21

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